A whole-cell pertussis vaccine engineered to elicit reduced reactogenicity protects baboons against pertussis challenge

A whole-cell pertussis vaccine engineered to elicit reduced reactogenicity protects baboons against pertussis challenge

ABSTRACT Whole-cell pertussis (wP) vaccines introduced in the 1940s led to a dramatic reduction of pertussis incidence and are still widely used in low- and middle-income countries (LMICs) worldwide. The reactogenicity of wP vaccines resulted in reduced public acceptance, which drove the development...

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Bibliographic Details
Main Authors: Parul Kapil, Yihui Wang, Kelsey Gregg, Lindsey Zimmerman, Damaris Molano, Jonatan Maldonado Villeda, Peter Sebo, Tod J. Merkel
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mSphere
Subjects:
whole cell vaccines
pertussis
baboon model
Online Access:https://journals.asm.org/doi/10.1128/msphere.00647-24
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https://journals.asm.org/doi/10.1128/msphere.00647-24

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