Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database
Objectives Dementia is common in people over the age of 65 years, with 80% of people with dementia older than 75 years. Previous studies have linked dementia to late-life depression, but the association between dementia and mid-life depression is poorly understood. Depression is a preventable and tr...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/10/e034924.full |
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| author | In-Hyuk Ha Boyoung Jung Ok-Cheol Yu Hoyeon Go Minjung Park |
| author_facet | In-Hyuk Ha Boyoung Jung Ok-Cheol Yu Hoyeon Go Minjung Park |
| author_sort | In-Hyuk Ha |
| collection | DOAJ |
| description | Objectives Dementia is common in people over the age of 65 years, with 80% of people with dementia older than 75 years. Previous studies have linked dementia to late-life depression, but the association between dementia and mid-life depression is poorly understood. Depression is a preventable and treatable medical condition, which means it is a modifiable factor that can potentially prevent or delay dementia. This study aimed to identify the association between dementia and depression within the life course.Design A nationwide, retrospective propensity score matched cohort study associating dementia with depression. Depression diagnosed between the ages of 45 and 64 years was classified as ‘mid-life’ and ‘late-life’ if diagnosed at 65 years or older. Patients were considered to have depression when one or more International Statistical Classification of Diseases and Related Health Problems, 10th revision codes for depression were recorded as primary or secondary diagnosis.Setting National Health Insurance Service-National Sample Cohort database of the National Health Insurance Service in South Korea, containing patient data from 2002 to 2013.Participants The study included 1824 and 374 852 patients in the case and control groups, respectively. A logistic regression analysis with complex sampling design was performed after adjusting for covariates, using the propensity score matching method without callipers, with a 1:1 nearest neighbour matching algorithm.Primary and secondary outcome measures The association of mid-onset and late-onset depression with dementia in terms of sociodemographic characteristics, such as sex and age, within the Korean population.Results Dementia was significantly associated with the presence of depression (OR=2.20, 95% CI=1.53–3.14); in particular, female patients with depression and patients aged 45–64 years with depression had increased odds of dementia (OR=2.65, 95% CI=1.78–3.93 and OR=2.72, 95% CI=1.41–5.24, respectively)Conclusion Depression is an associated factor for dementia, especially among people aged 45–64 years (mid-life). |
| format | Article |
| id | doaj-art-5f4ada8eb4a8430d9c9e41ce6b4e6294 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-5f4ada8eb4a8430d9c9e41ce6b4e62942024-11-16T17:05:09ZengBMJ Publishing GroupBMJ Open2044-60552020-10-01101010.1136/bmjopen-2019-034924Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort databaseIn-Hyuk Ha0Boyoung Jung1Ok-Cheol Yu2Hoyeon Go3Minjung Park4Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South KoreaDepartment of Health Administration, Hanyang Women’s University, Seoul, South KoreaDepartment of Korean rehabilitation medicine, Janseng Hospital of Korean Medicine, Seoul, Republic of KoreaKorean Internal Medicine, Semyung University, Korea, Chungju, Republic of KoreaNational Agency for Development of Innovative Technologies in Korean Medicine, National Institute of Korean Medicine Development, Seoul, Republic of KoreaObjectives Dementia is common in people over the age of 65 years, with 80% of people with dementia older than 75 years. Previous studies have linked dementia to late-life depression, but the association between dementia and mid-life depression is poorly understood. Depression is a preventable and treatable medical condition, which means it is a modifiable factor that can potentially prevent or delay dementia. This study aimed to identify the association between dementia and depression within the life course.Design A nationwide, retrospective propensity score matched cohort study associating dementia with depression. Depression diagnosed between the ages of 45 and 64 years was classified as ‘mid-life’ and ‘late-life’ if diagnosed at 65 years or older. Patients were considered to have depression when one or more International Statistical Classification of Diseases and Related Health Problems, 10th revision codes for depression were recorded as primary or secondary diagnosis.Setting National Health Insurance Service-National Sample Cohort database of the National Health Insurance Service in South Korea, containing patient data from 2002 to 2013.Participants The study included 1824 and 374 852 patients in the case and control groups, respectively. A logistic regression analysis with complex sampling design was performed after adjusting for covariates, using the propensity score matching method without callipers, with a 1:1 nearest neighbour matching algorithm.Primary and secondary outcome measures The association of mid-onset and late-onset depression with dementia in terms of sociodemographic characteristics, such as sex and age, within the Korean population.Results Dementia was significantly associated with the presence of depression (OR=2.20, 95% CI=1.53–3.14); in particular, female patients with depression and patients aged 45–64 years with depression had increased odds of dementia (OR=2.65, 95% CI=1.78–3.93 and OR=2.72, 95% CI=1.41–5.24, respectively)Conclusion Depression is an associated factor for dementia, especially among people aged 45–64 years (mid-life).https://bmjopen.bmj.com/content/10/10/e034924.full |
| spellingShingle | In-Hyuk Ha Boyoung Jung Ok-Cheol Yu Hoyeon Go Minjung Park Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database BMJ Open |
| title | Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database |
| title_full | Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database |
| title_fullStr | Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database |
| title_full_unstemmed | Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database |
| title_short | Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database |
| title_sort | association between dementia and depression a retrospective study using the korean national health insurance service national sample cohort database |
| url | https://bmjopen.bmj.com/content/10/10/e034924.full |
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