Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis.
The purpose of this study was to conduct a systematic review and meta-analysis to investigate the association between the utilization of metformin and the occurrence and survival rate of esophageal cancer (EC) in individuals with diabetes.<h4>Methods</h4>A systematic review and a meta-an...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0310687 |
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| _version_ | 1841533161670967296 |
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| author | Hui Xie Muhan Li Zhaoqi Chen Yuling Zheng |
| author_facet | Hui Xie Muhan Li Zhaoqi Chen Yuling Zheng |
| author_sort | Hui Xie |
| collection | DOAJ |
| description | The purpose of this study was to conduct a systematic review and meta-analysis to investigate the association between the utilization of metformin and the occurrence and survival rate of esophageal cancer (EC) in individuals with diabetes.<h4>Methods</h4>A systematic review and a meta-analysis were performed. Related literature was searched from databases, including PubMed, Embase, Web of Science, and Cochrane Library, covering the period from the inception of these databases until July 2023.<h4>Results</h4>A total of 16 studies were eligible, including twelve reporting incidences of EC and four reporting OS of EC patients. The combined findings revealed a significant association between the use of metformin and a lower risk of EC (OR, 0.87, P = 0.04). Furthermore, metformin could significantly prolong the OS time (HR, 0.87, P = 0.002). In analyses stratified by treatment modalities, metformin combined with surgery and neoadjuvant chemoradiotherapy presented the strongest protective effect on EC patients with diabetes (HR, 0.38, P = 0.003).<h4>Conclusion</h4>Our meta-analysis indicated that the use of metformin might reduce the EC incidence and improve the OS in EC patients with diabetes. |
| format | Article |
| id | doaj-art-5f406754a7c8484ea52b94f693531ff1 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5f406754a7c8484ea52b94f693531ff12025-01-17T05:31:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031068710.1371/journal.pone.0310687Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis.Hui XieMuhan LiZhaoqi ChenYuling ZhengThe purpose of this study was to conduct a systematic review and meta-analysis to investigate the association between the utilization of metformin and the occurrence and survival rate of esophageal cancer (EC) in individuals with diabetes.<h4>Methods</h4>A systematic review and a meta-analysis were performed. Related literature was searched from databases, including PubMed, Embase, Web of Science, and Cochrane Library, covering the period from the inception of these databases until July 2023.<h4>Results</h4>A total of 16 studies were eligible, including twelve reporting incidences of EC and four reporting OS of EC patients. The combined findings revealed a significant association between the use of metformin and a lower risk of EC (OR, 0.87, P = 0.04). Furthermore, metformin could significantly prolong the OS time (HR, 0.87, P = 0.002). In analyses stratified by treatment modalities, metformin combined with surgery and neoadjuvant chemoradiotherapy presented the strongest protective effect on EC patients with diabetes (HR, 0.38, P = 0.003).<h4>Conclusion</h4>Our meta-analysis indicated that the use of metformin might reduce the EC incidence and improve the OS in EC patients with diabetes.https://doi.org/10.1371/journal.pone.0310687 |
| spellingShingle | Hui Xie Muhan Li Zhaoqi Chen Yuling Zheng Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis. PLoS ONE |
| title | Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis. |
| title_full | Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis. |
| title_fullStr | Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis. |
| title_full_unstemmed | Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis. |
| title_short | Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis. |
| title_sort | association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0310687 |
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