Synthesis and Evaluation of Optical and PET GLP-1 Peptide Analogues for GLP-1R Imaging

Synthesis and Evaluation of Optical and PET GLP-1 Peptide Analogues for GLP-1R Imaging

A fluorescein-GLP-1 (7-37) analog was generated to determine GLP-1R distribution in various cell types of the pancreas in both strains of mice and receptor-specific uptake was confirmed by blocking with exendin-4. Biodistribution studies were carried out using 68 Ga-labeled GLP-1 (7-37) peptides in...

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Main Authors: Babak Behnam Azad, Vanessa Rota, Lihai Yu, Rebecca Mcgirr, André H. St. Amant, Ting-Yim Lee, Savita Dhanvantari, Leonard G. Luyt PhD
Format: Article
Language:English
Published: SAGE Publishing 2015-01-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2014.00057
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