Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study
Abstract Background Chronic obstructive pulmonary disease (COPD) is a widespread condition that significantly endangers human health. The C-reactive protein to albumin ratio (CAR) has been utilized as an important marker for the occurrence and development of various diseases. Nevertheless, the assoc...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-024-03469-w |
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| author | Ting Ao Yingxiu Huang Peng Zhen Ming Hu |
| author_facet | Ting Ao Yingxiu Huang Peng Zhen Ming Hu |
| author_sort | Ting Ao |
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| description | Abstract Background Chronic obstructive pulmonary disease (COPD) is a widespread condition that significantly endangers human health. The C-reactive protein to albumin ratio (CAR) has been utilized as an important marker for the occurrence and development of various diseases. Nevertheless, the association between CAR and COPD remains inadequately explored. This research aimed to examine the link between the CAR and COPD. Methods This cross-sectional study examined data from adult participants in the National Health and Nutrition Examination Survey between 1999 and 2010. The identification of COPD relied on data obtained directly from self-reported information. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between CAR and COPD. Additionally, subgroup and sensitivity analyses were performed to evaluate the stability of the observed relationship. Results The study comprised 24,627 participants, among whom 1,809 had COPD. After adjusting for potential confounders, CAR was found to be associated with COPD (OR 1.37; 95% CI, 1.12–1.69; P = 0.003). In the analysis comparing individuals in the lowest CAR tertile (T1) with those in the highest, the adjusted OR for COPD was 1.39 (95% CI, 1.17–1.65; P < 0.001). Validation through subgroup and sensitivity analyses further strengthened the stability and consistency of the study’s findings. Conclusion Elevated levels of the CAR were correlated with an increased risk of COPD. Clinical trial number : not applicable. |
| format | Article |
| id | doaj-art-5f35744f19b2419b9c4a0055dd5aafd1 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-5f35744f19b2419b9c4a0055dd5aafd12025-01-05T12:07:26ZengBMCBMC Pulmonary Medicine1471-24662025-01-0125111010.1186/s12890-024-03469-wAssociation between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional studyTing Ao0Yingxiu Huang1Peng Zhen2Ming Hu3Department of Infectious Diseases, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Infectious Diseases, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Infectious Diseases, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Infectious Diseases, Beijing Luhe Hospital, Capital Medical UniversityAbstract Background Chronic obstructive pulmonary disease (COPD) is a widespread condition that significantly endangers human health. The C-reactive protein to albumin ratio (CAR) has been utilized as an important marker for the occurrence and development of various diseases. Nevertheless, the association between CAR and COPD remains inadequately explored. This research aimed to examine the link between the CAR and COPD. Methods This cross-sectional study examined data from adult participants in the National Health and Nutrition Examination Survey between 1999 and 2010. The identification of COPD relied on data obtained directly from self-reported information. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between CAR and COPD. Additionally, subgroup and sensitivity analyses were performed to evaluate the stability of the observed relationship. Results The study comprised 24,627 participants, among whom 1,809 had COPD. After adjusting for potential confounders, CAR was found to be associated with COPD (OR 1.37; 95% CI, 1.12–1.69; P = 0.003). In the analysis comparing individuals in the lowest CAR tertile (T1) with those in the highest, the adjusted OR for COPD was 1.39 (95% CI, 1.17–1.65; P < 0.001). Validation through subgroup and sensitivity analyses further strengthened the stability and consistency of the study’s findings. Conclusion Elevated levels of the CAR were correlated with an increased risk of COPD. Clinical trial number : not applicable.https://doi.org/10.1186/s12890-024-03469-wChronic obstructive pulmonary diseaseC-reactive protein to albumin ratioInflammationNutritional statusNational Health and Nutrition Examination Survey |
| spellingShingle | Ting Ao Yingxiu Huang Peng Zhen Ming Hu Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study BMC Pulmonary Medicine Chronic obstructive pulmonary disease C-reactive protein to albumin ratio Inflammation Nutritional status National Health and Nutrition Examination Survey |
| title | Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study |
| title_full | Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study |
| title_fullStr | Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study |
| title_full_unstemmed | Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study |
| title_short | Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study |
| title_sort | association between c reactive protein to albumin ratio and chronic obstructive pulmonary disease a cross sectional study |
| topic | Chronic obstructive pulmonary disease C-reactive protein to albumin ratio Inflammation Nutritional status National Health and Nutrition Examination Survey |
| url | https://doi.org/10.1186/s12890-024-03469-w |
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