Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study
Objectives The use of psychoactive prescription medication is increasing in the general population. This is a cause for concern, particularly among the elderly, where physiological changes related to senescence increase the risk for adverse effects. While previous studies regarding psychoactive subs...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e032572.full |
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| author | Stig Tore Bogstrand Thomas Berg Anners Lerdal Danil Gamboa Benedicte Jørgenrud Evgeny A Bryun Vigdis Vindenes Evgenya A Koshkina Aleksei V Nadezhdin Saranda Kabashi Elena J Tetenova Anna Armika Tussilago Nyman Alexey J Kolgashkin Aleksei E Petukhov Sergey N Perekhodov Elena N Davydova Gudmund Nordby |
| author_facet | Stig Tore Bogstrand Thomas Berg Anners Lerdal Danil Gamboa Benedicte Jørgenrud Evgeny A Bryun Vigdis Vindenes Evgenya A Koshkina Aleksei V Nadezhdin Saranda Kabashi Elena J Tetenova Anna Armika Tussilago Nyman Alexey J Kolgashkin Aleksei E Petukhov Sergey N Perekhodov Elena N Davydova Gudmund Nordby |
| author_sort | Stig Tore Bogstrand |
| collection | DOAJ |
| description | Objectives The use of psychoactive prescription medication is increasing in the general population. This is a cause for concern, particularly among the elderly, where physiological changes related to senescence increase the risk for adverse effects. While previous studies regarding psychoactive substance use have generally been population based, we sought to determine the frequency of such use among acutely hospitalised patients.Setting Two emergency departments (EDs), one in Oslo and one in Moscow, admitting patients to Departments of Internal Medicine.Participants 5583 patients aged ≥18 years participated, distributed evenly between genders and study locations. Patients unable to give informed consent were excluded. The study sites did not admit patients with surgical conditions and/or injuries.Primary and secondary outcomes The presence of psychoactive substances was determined through blood analysis using liquid chromatography-mass spectrometry. Secondary outcomes comprised demographic data (including age, gender, employment and marital status), degree of psychological distress, concurrent alcohol use, and self-reported alcohol, psychoactive drug and illicit substance use.Results 32.3% in Oslo and 12% in Moscow were positive for one or more psychoactive medicinal drugs (benzodiazepines, z-hypnotics, opioids or barbiturates). In Oslo, medicinal drug use was associated with being aged 61 to 70 years (OR 2.40, 95% CI 1.61 to 3.58) compared with 18 to 40 years, and psychological distress (OR 2.61, 95% CI 2.06 to 3.30). In Moscow, psychoactive medicinal drug use was also associated with psychological distress (OR 1.68, 95% CI 1.18 to 2.39), and was less common among patients aged 41 to 60 years (OR 0.62, 95% CI 0.43 to 0.88) than among patients aged 18 to 40 years.Conclusion A significant proportion of admitted patients used one or more psychoactive medicinal drugs, in particular benzodiazepines (Oslo and Moscow) and opiates (Oslo). We suggest formalised screening for inappropriate prescription drug use and increased adherence to clinical prescription guidelines. |
| format | Article |
| id | doaj-art-5f0d48fc8364422ea448271f5ac1c4e8 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-5f0d48fc8364422ea448271f5ac1c4e82025-01-07T12:45:13ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-032572Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational studyStig Tore Bogstrand0Thomas Berg1Anners Lerdal2Danil Gamboa3Benedicte Jørgenrud4Evgeny A Bryun5Vigdis Vindenes6Evgenya A Koshkina7Aleksei V Nadezhdin8Saranda Kabashi9Elena J Tetenova10Anna Armika Tussilago Nyman11Alexey J Kolgashkin12Aleksei E Petukhov13Sergey N Perekhodov14Elena N Davydova15Gudmund Nordby16Department of Public Health Science, University of Oslo, Oslo, NorwayDepartment of Forensic Sciences, Oslo University Hospital, Oslo, NorwayDepartment of Interdiciplinary Health Sciencies, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, NorwayInstitute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Forensic Sciences, Oslo University Hospital, Oslo, NorwayMoscow Research and Practical Centre on Addictions, Moscow Department of Health, Moscow, RussiaDepartment of Forensic Sciences, Oslo University Hospital, Oslo, NorwayMoscow Research and Practical Centre on Addictions, Moscow Department of Health, Moscow, RussiaMoscow Research and Practical Centre on Addictions, Moscow Department of Health, Moscow, RussiaDepartment of Forensic Sciences, Oslo University Hospital, Oslo, NorwayMoscow Research and Practical Centre on Addictions, Moscow Department of Health, Moscow, RussiaDepartment of Forensic Sciences, Oslo University Hospital, Oslo, NorwayMoscow Research and Practical Centre on Addictions, Moscow Department of Health, Moscow, RussiaMoscow Research and Practical Centre on Addictions, Moscow Department of Health, Moscow, RussiaDemikhov Moscow Clinical Hospital, Moscow, RussiaDemikhov Moscow Clinical Hospital, Moscow, RussiaDepartment of Internal Medicine, Lovisenberg Diaconal Hospital, Oslo, NorwayObjectives The use of psychoactive prescription medication is increasing in the general population. This is a cause for concern, particularly among the elderly, where physiological changes related to senescence increase the risk for adverse effects. While previous studies regarding psychoactive substance use have generally been population based, we sought to determine the frequency of such use among acutely hospitalised patients.Setting Two emergency departments (EDs), one in Oslo and one in Moscow, admitting patients to Departments of Internal Medicine.Participants 5583 patients aged ≥18 years participated, distributed evenly between genders and study locations. Patients unable to give informed consent were excluded. The study sites did not admit patients with surgical conditions and/or injuries.Primary and secondary outcomes The presence of psychoactive substances was determined through blood analysis using liquid chromatography-mass spectrometry. Secondary outcomes comprised demographic data (including age, gender, employment and marital status), degree of psychological distress, concurrent alcohol use, and self-reported alcohol, psychoactive drug and illicit substance use.Results 32.3% in Oslo and 12% in Moscow were positive for one or more psychoactive medicinal drugs (benzodiazepines, z-hypnotics, opioids or barbiturates). In Oslo, medicinal drug use was associated with being aged 61 to 70 years (OR 2.40, 95% CI 1.61 to 3.58) compared with 18 to 40 years, and psychological distress (OR 2.61, 95% CI 2.06 to 3.30). In Moscow, psychoactive medicinal drug use was also associated with psychological distress (OR 1.68, 95% CI 1.18 to 2.39), and was less common among patients aged 41 to 60 years (OR 0.62, 95% CI 0.43 to 0.88) than among patients aged 18 to 40 years.Conclusion A significant proportion of admitted patients used one or more psychoactive medicinal drugs, in particular benzodiazepines (Oslo and Moscow) and opiates (Oslo). We suggest formalised screening for inappropriate prescription drug use and increased adherence to clinical prescription guidelines.https://bmjopen.bmj.com/content/10/9/e032572.full |
| spellingShingle | Stig Tore Bogstrand Thomas Berg Anners Lerdal Danil Gamboa Benedicte Jørgenrud Evgeny A Bryun Vigdis Vindenes Evgenya A Koshkina Aleksei V Nadezhdin Saranda Kabashi Elena J Tetenova Anna Armika Tussilago Nyman Alexey J Kolgashkin Aleksei E Petukhov Sergey N Perekhodov Elena N Davydova Gudmund Nordby Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study BMJ Open |
| title | Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study |
| title_full | Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study |
| title_fullStr | Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study |
| title_full_unstemmed | Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study |
| title_short | Prevalence of psychoactive substance use among acutely hospitalised patients in Oslo and Moscow: a cross-sectional, observational study |
| title_sort | prevalence of psychoactive substance use among acutely hospitalised patients in oslo and moscow a cross sectional observational study |
| url | https://bmjopen.bmj.com/content/10/9/e032572.full |
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