Single-cell and spatial transcriptomics reveal SPP1-CD44 signaling drives primary resistance to immune checkpoint inhibitors in RCC

Single-cell and spatial transcriptomics reveal SPP1-CD44 signaling drives primary resistance to immune checkpoint inhibitors in RCC

Abstract Background Immune checkpoint inhibitors (ICIs) are a cornerstone therapy for advanced renal cell carcinoma (RCC). However, significant rates of primary resistance hinder their efficacy, and the underlying mechanisms remain poorly understood. This study aims to unravel the tumor-immune inter...

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Bibliographic Details
Main Authors: Junfeng Zhang, Qingyan Peng, Jin Fan, Fuzhong Liu, Hongbo Chen, Xing Bi, Shuai Yuan, Wei Jiang, Ting Pan, Kailing Li, Sihai Tan, Peng Chen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Advanced renal cell carcinoma
Primary resistance
SPP1-CD44 signaling
Cell–cell communication
MAPK signaling
Online Access:https://doi.org/10.1186/s12967-024-06018-5
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