Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy
Cancer is a major killer threatening modern human health and a leading cause of death worldwide. Due to the heterogeneity and complexity of cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number of researchers and medical professionals are working to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1526612/full |
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| author | Sizuo Yan Yu Gan Huizhe Xu Huizhe Xu Haozhe Piao Haozhe Piao |
| author_facet | Sizuo Yan Yu Gan Huizhe Xu Huizhe Xu Haozhe Piao Haozhe Piao |
| author_sort | Sizuo Yan |
| collection | DOAJ |
| description | Cancer is a major killer threatening modern human health and a leading cause of death worldwide. Due to the heterogeneity and complexity of cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number of researchers and medical professionals are working to develop new ways to treat cancer. Bacteria have chemotaxis that can target and colonize tumor tissue, as well as activate anti-tumor immune responses, which makes them ideal for biomedical applications. With the rapid development of nanomedicine and synthetic biology technologies, bacteria are extensively used as carriers for drug delivery to treat tumors, which holds the promise of overcoming the limitations of conventional cancer treatment regimens. This paper summarizes examples of anti-cancer drugs delivered by bacterial carriers, and their strengths and weaknesses. Further, we emphasize the promise of bacterial carrier delivery systems in clinical translation. |
| format | Article |
| id | doaj-art-5ef081afc3164a18ba63ebbcdaf12e14 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-5ef081afc3164a18ba63ebbcdaf12e142025-01-08T06:11:46ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.15266121526612Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapySizuo Yan0Yu Gan1Huizhe Xu2Huizhe Xu3Haozhe Piao4Haozhe Piao5Department of Neurosurgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Shenyang, ChinaDepartment of Neurosurgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Shenyang, ChinaInstitute of Cancer Medicine, Dalian University of Technology, Dalian, ChinaCentral Laboratory, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Shenyang, ChinaDepartment of Neurosurgery, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Shenyang, ChinaInstitute of Cancer Medicine, Dalian University of Technology, Dalian, ChinaCancer is a major killer threatening modern human health and a leading cause of death worldwide. Due to the heterogeneity and complexity of cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number of researchers and medical professionals are working to develop new ways to treat cancer. Bacteria have chemotaxis that can target and colonize tumor tissue, as well as activate anti-tumor immune responses, which makes them ideal for biomedical applications. With the rapid development of nanomedicine and synthetic biology technologies, bacteria are extensively used as carriers for drug delivery to treat tumors, which holds the promise of overcoming the limitations of conventional cancer treatment regimens. This paper summarizes examples of anti-cancer drugs delivered by bacterial carriers, and their strengths and weaknesses. Further, we emphasize the promise of bacterial carrier delivery systems in clinical translation.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1526612/fullbacteriabacterial derivativesdrug deliverybacteriotherapycancer |
| spellingShingle | Sizuo Yan Yu Gan Huizhe Xu Huizhe Xu Haozhe Piao Haozhe Piao Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy Frontiers in Bioengineering and Biotechnology bacteria bacterial derivatives drug delivery bacteriotherapy cancer |
| title | Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy |
| title_full | Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy |
| title_fullStr | Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy |
| title_full_unstemmed | Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy |
| title_short | Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy |
| title_sort | bacterial carrier mediated drug delivery systems a promising strategy in cancer therapy |
| topic | bacteria bacterial derivatives drug delivery bacteriotherapy cancer |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1526612/full |
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