Immunogenic clearance combined with PD-1 blockade elicits antitumor effect by promoting the recruitment and expansion of the effector memory-like CD8+ T cell

Immunogenic clearance combined with PD-1 blockade elicits antitumor effect by promoting the recruitment and expansion of the effector memory-like CD8+ T cell

Immune checkpoint inhibition shows promise for cancer treatment, but only a minority of patients respond. Combination strategies have been explored to overcome this resistance. Combining immunogenic clearance using immunogenic cell death inducers with a rho kinase inhibitor enhances phagocytosis of...

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Bibliographic Details
Main Authors: Seong A Kim, Seohyun Kim, Yeonsun Hong, Yoonjeong Choi, Yeji Lee, Minsu Kwon, Seung-Yoon Park, Cherlhyun Jeong, Gi-Hoon Nam, Rafael T. Han, In-San Kim
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Translational Oncology
Subjects:
Immunotherapy
Immune checkpoint inhibitor
CD8+ T cell
Combination therapy
Single cell RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332400336X
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