Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healing
Objective: to conduct a morphological (histological) study of the effect of a designed collagen bandage on grade IIIa burn wound healing.Materials and methods. Wound biopsy specimens taken from 19 patients (mean age 50 years) with grade IIIa burns (10 to 60% of the body surface) were examined. A typ...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2018-08-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/296 |
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| author | E. G. Kolokolchikova M. V. Sychevsky E. A. Zhirkova S. V. Smirnov V. S. Bocharova |
| author_facet | E. G. Kolokolchikova M. V. Sychevsky E. A. Zhirkova S. V. Smirnov V. S. Bocharova |
| author_sort | E. G. Kolokolchikova |
| collection | DOAJ |
| description | Objective: to conduct a morphological (histological) study of the effect of a designed collagen bandage on grade IIIa burn wound healing.Materials and methods. Wound biopsy specimens taken from 19 patients (mean age 50 years) with grade IIIa burns (10 to 60% of the body surface) were examined. A type I collagen-based biological bandage was used for their treatment. The wounds of the patients who were treated with a levomecol ointment-containing bandage served as a control. The healing of Grade IIIa burn wounds, by applying a type I collagenbased platelet-derived growth factor BB (PDGF-BB)-enriched biological bandage, was histologically studied.Results. Burn wound epitheliazation was observed on days 7 to 9 when the collagen-based bandage was applied. It was seen in the controls on days 20-22 if the course of the wound process was favorable.Conclusion. The application of the type 1 collagen-type PDGF-BB biological bandage on days 1-2 after injury considerably accelerated grade IIIa burn wound healing processes. The stimulating effect of the bandage is likely to be associated mainly with the fact that in the early stage of the wound healing process, exogenous collagen of the bandage creates the conditions that are necessary for the fixation and movement of cells (both keratinocytes and fibroblasts). |
| format | Article |
| id | doaj-art-5ece5646052e456f8b68013ef7e4a9f8 |
| institution | Kabale University |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-5ece5646052e456f8b68013ef7e4a9f82025-08-20T03:56:37ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092018-08-0103-4646710.23873/2074-0506-2010-0-3-4-64-67285Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healingE. G. Kolokolchikova0M. V. Sychevsky1E. A. Zhirkova2S. V. Smirnov3V. S. Bocharova4N.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareObjective: to conduct a morphological (histological) study of the effect of a designed collagen bandage on grade IIIa burn wound healing.Materials and methods. Wound biopsy specimens taken from 19 patients (mean age 50 years) with grade IIIa burns (10 to 60% of the body surface) were examined. A type I collagen-based biological bandage was used for their treatment. The wounds of the patients who were treated with a levomecol ointment-containing bandage served as a control. The healing of Grade IIIa burn wounds, by applying a type I collagenbased platelet-derived growth factor BB (PDGF-BB)-enriched biological bandage, was histologically studied.Results. Burn wound epitheliazation was observed on days 7 to 9 when the collagen-based bandage was applied. It was seen in the controls on days 20-22 if the course of the wound process was favorable.Conclusion. The application of the type 1 collagen-type PDGF-BB biological bandage on days 1-2 after injury considerably accelerated grade IIIa burn wound healing processes. The stimulating effect of the bandage is likely to be associated mainly with the fact that in the early stage of the wound healing process, exogenous collagen of the bandage creates the conditions that are necessary for the fixation and movement of cells (both keratinocytes and fibroblasts).https://www.jtransplantologiya.ru/jour/article/view/296intercellular matrixstem cellburnscollagen-based bandagemorphology |
| spellingShingle | E. G. Kolokolchikova M. V. Sychevsky E. A. Zhirkova S. V. Smirnov V. S. Bocharova Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healing Трансплантология (Москва) intercellular matrix stem cell burns collagen-based bandage morphology |
| title | Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healing |
| title_full | Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healing |
| title_fullStr | Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healing |
| title_full_unstemmed | Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healing |
| title_short | Morphological evaluation of the effect of collagen bandage on grade IIIa burn wound healing |
| title_sort | morphological evaluation of the effect of collagen bandage on grade iiia burn wound healing |
| topic | intercellular matrix stem cell burns collagen-based bandage morphology |
| url | https://www.jtransplantologiya.ru/jour/article/view/296 |
| work_keys_str_mv | AT egkolokolchikova morphologicalevaluationoftheeffectofcollagenbandageongradeiiiaburnwoundhealing AT mvsychevsky morphologicalevaluationoftheeffectofcollagenbandageongradeiiiaburnwoundhealing AT eazhirkova morphologicalevaluationoftheeffectofcollagenbandageongradeiiiaburnwoundhealing AT svsmirnov morphologicalevaluationoftheeffectofcollagenbandageongradeiiiaburnwoundhealing AT vsbocharova morphologicalevaluationoftheeffectofcollagenbandageongradeiiiaburnwoundhealing |