Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model

Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model

Parkinson’s disease (PD) is a neurodegenerative condition characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) of the brain, manifesting itself with both motor and non-motor symptoms. A critical element of this pathology is neuroinflammation, which triggers a...

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Bibliographic Details
Main Authors: Maria E. Bianchetti, Ana Flavia F. Ferreira, Luiz R. G. Britto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Neuroanatomy
Subjects:
neurodegeneration
neuroprotection
neuroinflammation
microglia
Parkinson’s disease
6-hydroxydopamine
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2024.1511951/full
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