Carrier rocket-inspired hydrogel microspheres targeting subchondral bone osteoclast activity alleviate osteoarthritic pain and cartilage degeneration

Carrier rocket-inspired hydrogel microspheres targeting subchondral bone osteoclast activity alleviate osteoarthritic pain and cartilage degeneration

Abstract Background Osteoarthritis (OA) represents a major global health challenge, characterized by progressive cartilage degeneration and subchondral bone remodeling, which culminate in debilitating pain and functional impairment. While recent studies have underscored the pivotal role of activated...

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Main Authors: Zhenglin Zhu, Yujia Luo, Pengcheng Xiao, Yi Xie, Jun Zhang, Ke Huang, Xiangdong Wu, Ke Lu, Yuting Zhang, Jianye Tan, Hong Chen, Wei Huang, Yiting Lei, Junyi Liao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Nanobiotechnology
Subjects:
Osteoarthritis
Polyamidoamine
Hydrogel microspheres
Pain therapy
Cartilage degeneration
Online Access:https://doi.org/10.1186/s12951-025-03598-2
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