Novel chlorine-containing curcumin analogue CAK06 promotes neuroprotection and rapid antidepressant through Nrf2-induced anti-inflammatory and antioxidant effects

Novel chlorine-containing curcumin analogue CAK06 promotes neuroprotection and rapid antidepressant through Nrf2-induced anti-inflammatory and antioxidant effects

Currently, conventional antidepressants are often limited by poor efficacy and delayed onset, and there is an urgent need for the development of rapid acting antidepressant alternatives. The aim of this study was to develop novel antidepressants with a rapid onset of action by inhibiting inflammatio...

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Bibliographic Details
Main Authors: Tao Chen, Suyu Yin, Ruxu Yue, Chao Pi, Ying Zuo, Yongqiang Jiang, Wenwu Zheng, Jun Jiang, Yan Yang, Shifeng Chu, Kezhi Liu, Yumeng Wei, Ling Zhao
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neurotherapeutics
Subjects:
Depression
Neuroprotection
Oxidative stress
Curcumin analogues
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747925000789
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http://www.sciencedirect.com/science/article/pii/S1878747925000789

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