Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation
Hypoxia-inducible factors (HIFs) are central regulators of gene expression in response to oxygen deprivation, a common feature in critical illnesses. The significant burden that critical illnesses place on global healthcare systems highlights the need for a deeper understanding of underlying mechani...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/1/29 |
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| author | Nikolaos S. Lotsios Chrysi Keskinidou Sotirios P. Karagiannis Kostas A. Papavassiliou Athanasios G. Papavassiliou Anastasia Kotanidou Ioanna Dimopoulou Stylianos E. Orfanos Alice G. Vassiliou |
| author_facet | Nikolaos S. Lotsios Chrysi Keskinidou Sotirios P. Karagiannis Kostas A. Papavassiliou Athanasios G. Papavassiliou Anastasia Kotanidou Ioanna Dimopoulou Stylianos E. Orfanos Alice G. Vassiliou |
| author_sort | Nikolaos S. Lotsios |
| collection | DOAJ |
| description | Hypoxia-inducible factors (HIFs) are central regulators of gene expression in response to oxygen deprivation, a common feature in critical illnesses. The significant burden that critical illnesses place on global healthcare systems highlights the need for a deeper understanding of underlying mechanisms and the development of innovative treatment strategies. Among critical illnesses, impaired lung function is frequently linked to hypoxic conditions. This review focuses on the expression and regulation of HIF signalling in experimental models of acute lung injury (ALI) and clinical studies in critically ill patients with acute respiratory distress syndrome (ARDS). We explore the potential dual role of HIF signalling in acute lung inflammation. Furthermore, its role in key biological processes and its potential prognostic significance in clinical scenarios are discussed. Finally, we explore recent pharmacological advancements targeting HIF signalling, which have emerged as promising alternatives to existing therapeutic approaches, potentially enabling more effective management strategies. |
| format | Article |
| id | doaj-art-5e941517cff44f38a58e8dc01f9253f1 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-5e941517cff44f38a58e8dc01f9253f12025-01-10T13:16:18ZengMDPI AGCells2073-44092024-12-011412910.3390/cells14010029Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung InflammationNikolaos S. Lotsios0Chrysi Keskinidou1Sotirios P. Karagiannis2Kostas A. Papavassiliou3Athanasios G. Papavassiliou4Anastasia Kotanidou5Ioanna Dimopoulou6Stylianos E. Orfanos7Alice G. Vassiliou8First Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceFirst Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceFirst Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceFirst University Department of Respiratory Medicine, ‘Sotiria’ Chest Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceFirst Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceFirst Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceFirst Department of Critical Care Medicine, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, GreeceHypoxia-inducible factors (HIFs) are central regulators of gene expression in response to oxygen deprivation, a common feature in critical illnesses. The significant burden that critical illnesses place on global healthcare systems highlights the need for a deeper understanding of underlying mechanisms and the development of innovative treatment strategies. Among critical illnesses, impaired lung function is frequently linked to hypoxic conditions. This review focuses on the expression and regulation of HIF signalling in experimental models of acute lung injury (ALI) and clinical studies in critically ill patients with acute respiratory distress syndrome (ARDS). We explore the potential dual role of HIF signalling in acute lung inflammation. Furthermore, its role in key biological processes and its potential prognostic significance in clinical scenarios are discussed. Finally, we explore recent pharmacological advancements targeting HIF signalling, which have emerged as promising alternatives to existing therapeutic approaches, potentially enabling more effective management strategies.https://www.mdpi.com/2073-4409/14/1/29ARDSHIFhypoxiaacute lung injury |
| spellingShingle | Nikolaos S. Lotsios Chrysi Keskinidou Sotirios P. Karagiannis Kostas A. Papavassiliou Athanasios G. Papavassiliou Anastasia Kotanidou Ioanna Dimopoulou Stylianos E. Orfanos Alice G. Vassiliou Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation Cells ARDS HIF hypoxia acute lung injury |
| title | Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation |
| title_full | Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation |
| title_fullStr | Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation |
| title_full_unstemmed | Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation |
| title_short | Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation |
| title_sort | expression and regulation of hypoxia inducible factor signalling in acute lung inflammation |
| topic | ARDS HIF hypoxia acute lung injury |
| url | https://www.mdpi.com/2073-4409/14/1/29 |
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