Assessing XEN microstent’s one-year efficacy: independent of site variability
AIM: To evaluate the short-term efficacy of XEN45 Gel Stent (XEN) implantation for primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma across two university eye clinics, aiming to assess the impact of varying center-specific protocols during the first postoperative year. METHODS:...
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| Format: | Article |
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-01-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/1/20250110.pdf |
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| author | Caroline Bormann Catharina Busch Matus Rehak Christian Thomas Scharenberg Focke Ziemssen Jan Darius Unterlauft |
| author_facet | Caroline Bormann Catharina Busch Matus Rehak Christian Thomas Scharenberg Focke Ziemssen Jan Darius Unterlauft |
| author_sort | Caroline Bormann |
| collection | DOAJ |
| description | AIM: To evaluate the short-term efficacy of XEN45 Gel Stent (XEN) implantation for primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma across two university eye clinics, aiming to assess the impact of varying center-specific protocols during the first postoperative year. METHODS: We retrospectively examined 282 patients (183 in center 1, 99 in center 2), who underwent XEN microstent implantation for uncontrolled POAG or PEX glaucoma. Parameters including intraocular pressure (IOP), IOP-lowering medication count, best corrected visual acuity (BCVA), and postoperative complications were evaluated over 12mo. RESULTS: Post-implantation, center 1 reported a mean IOP reduction from 25.3±7.4 to 14.1±4.7 mm Hg (P<0.01) and a decrease in IOP-lowering medications from 3.2±1.2 to 1.0±1.3 (P<0.01). Center 2 observed a similar reduction from 24.4±6.5 to 15.1±5.5 mm Hg (P<0.01) and medication decrease from 3.0±1.1 to 1.2±1.0 (P<0.01). BCVA remained stable in both cohorts. The most common complications were hypotony (center 1: 32; center 2: 20) and choroidal detachment (center 1: 22, center 2: 15), with nearly identical needling rates (40% in center 1, 41% in center 2). CONCLUSION: XEN implantation yields consistent reductions in IOP and medication use across different centers using comparable surgical and postoperative treatment regime. These findings underscore XEN's short-term effectiveness and suggest standardizable outcomes regardless of exact surgical procedure or treatment differences. |
| format | Article |
| id | doaj-art-5e5a820e9f1849958fa051abc988a6af |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-5e5a820e9f1849958fa051abc988a6af2024-12-18T07:46:07ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-01-01181869310.18240/ijo.2025.01.1020250110Assessing XEN microstent’s one-year efficacy: independent of site variabilityCaroline Bormann0Catharina Busch1Matus Rehak2Christian Thomas Scharenberg3Focke Ziemssen4Jan Darius Unterlauft5Caroline Bormann. Department of Ophthalmology, University of Leipzig, Liebigstraße 10-14, Leipzig 04103, Germany. caroline.bormann@medizin.uni-leipzig.deDepartment of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, Leipzig 04103, GermanyDepartment of Ophthalmology, University of Innsbruck, Anichstraße 35, Innsbruck 6020, AustriaSmile Eyes Augen- und Laserzentrum Leipzig, Lampestraße 1, Leipzig 04107, GermanyDepartment of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, Leipzig 04103, GermanyDepartment of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, Leipzig 04103, Germany; Department of Ophthalmology, Inselspital, University of Bern, Freiburgstrasse 4, Bern 3010, SwitzerlandAIM: To evaluate the short-term efficacy of XEN45 Gel Stent (XEN) implantation for primary open angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma across two university eye clinics, aiming to assess the impact of varying center-specific protocols during the first postoperative year. METHODS: We retrospectively examined 282 patients (183 in center 1, 99 in center 2), who underwent XEN microstent implantation for uncontrolled POAG or PEX glaucoma. Parameters including intraocular pressure (IOP), IOP-lowering medication count, best corrected visual acuity (BCVA), and postoperative complications were evaluated over 12mo. RESULTS: Post-implantation, center 1 reported a mean IOP reduction from 25.3±7.4 to 14.1±4.7 mm Hg (P<0.01) and a decrease in IOP-lowering medications from 3.2±1.2 to 1.0±1.3 (P<0.01). Center 2 observed a similar reduction from 24.4±6.5 to 15.1±5.5 mm Hg (P<0.01) and medication decrease from 3.0±1.1 to 1.2±1.0 (P<0.01). BCVA remained stable in both cohorts. The most common complications were hypotony (center 1: 32; center 2: 20) and choroidal detachment (center 1: 22, center 2: 15), with nearly identical needling rates (40% in center 1, 41% in center 2). CONCLUSION: XEN implantation yields consistent reductions in IOP and medication use across different centers using comparable surgical and postoperative treatment regime. These findings underscore XEN's short-term effectiveness and suggest standardizable outcomes regardless of exact surgical procedure or treatment differences.http://ies.ijo.cn/en_publish/2025/1/20250110.pdfglaucomaxen45 gel stentminimally invasive glaucoma surgery |
| spellingShingle | Caroline Bormann Catharina Busch Matus Rehak Christian Thomas Scharenberg Focke Ziemssen Jan Darius Unterlauft Assessing XEN microstent’s one-year efficacy: independent of site variability International Journal of Ophthalmology glaucoma xen45 gel stent minimally invasive glaucoma surgery |
| title | Assessing XEN microstent’s one-year efficacy: independent of site variability |
| title_full | Assessing XEN microstent’s one-year efficacy: independent of site variability |
| title_fullStr | Assessing XEN microstent’s one-year efficacy: independent of site variability |
| title_full_unstemmed | Assessing XEN microstent’s one-year efficacy: independent of site variability |
| title_short | Assessing XEN microstent’s one-year efficacy: independent of site variability |
| title_sort | assessing xen microstent s one year efficacy independent of site variability |
| topic | glaucoma xen45 gel stent minimally invasive glaucoma surgery |
| url | http://ies.ijo.cn/en_publish/2025/1/20250110.pdf |
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