Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach
We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PA...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/726207 |
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| author | M. B. I. Lobbes M. E. Kooi E. Lutgens A. W. Ruiters V. Lima Passos S. H. J. G. Braat M. Rousch H. Ten Cate J. M. A. van Engelshoven M. J. A. P. Daemen S. Heeneman |
| author_facet | M. B. I. Lobbes M. E. Kooi E. Lutgens A. W. Ruiters V. Lima Passos S. H. J. G. Braat M. Rousch H. Ten Cate J. M. A. van Engelshoven M. J. A. P. Daemen S. Heeneman |
| author_sort | M. B. I. Lobbes |
| collection | DOAJ |
| description | We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk. |
| format | Article |
| id | doaj-art-5e519b7f1c584261a193542bf7124cdc |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-5e519b7f1c584261a193542bf7124cdc2025-02-03T05:47:20ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322010-01-01201010.1155/2010/726207726207Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker ApproachM. B. I. Lobbes0M. E. Kooi1E. Lutgens2A. W. Ruiters3V. Lima Passos4S. H. J. G. Braat5M. Rousch6H. Ten Cate7J. M. A. van Engelshoven8M. J. A. P. Daemen9S. Heeneman10Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Cardiology, Orbis Medical Center, P.O. Box 5500, 6130 MB Sittard, The NetherlandsDepartment of Methodology and Statistics, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The NetherlandsDepartment of Cardiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsWe evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.http://dx.doi.org/10.1155/2010/726207 |
| spellingShingle | M. B. I. Lobbes M. E. Kooi E. Lutgens A. W. Ruiters V. Lima Passos S. H. J. G. Braat M. Rousch H. Ten Cate J. M. A. van Engelshoven M. J. A. P. Daemen S. Heeneman Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach International Journal of Vascular Medicine |
| title | Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach |
| title_full | Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach |
| title_fullStr | Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach |
| title_full_unstemmed | Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach |
| title_short | Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach |
| title_sort | leukocyte counts myeloperoxidase and pregnancy associated plasma protein a as biomarkers for cardiovascular disease towards a multi biomarker approach |
| url | http://dx.doi.org/10.1155/2010/726207 |
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