Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting
Nanoparticles (NPs) are widely used platforms for delivery of various biologically active compounds. Unfortunately, there is a lack of comprehensive investigations that would include a few types of NPs with different physicochemical parameters and their potential use as delivery systems in one tumor...
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| Format: | Article |
| Language: | English |
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Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2024-05-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/7695 |
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| author | Alisa S. Postovalova Yulia A. Tishchenko Vladislava A. Rusakova Timofey E. Karpov Nina V. Gavrilova Anna S. Rogova Irina A. Gorbunova Alexander S. Timin |
| author_facet | Alisa S. Postovalova Yulia A. Tishchenko Vladislava A. Rusakova Timofey E. Karpov Nina V. Gavrilova Anna S. Rogova Irina A. Gorbunova Alexander S. Timin |
| author_sort | Alisa S. Postovalova |
| collection | DOAJ |
| description | Nanoparticles (NPs) are widely used platforms for delivery of various biologically active compounds. Unfortunately, there is a lack of comprehensive investigations that would include a few types of NPs with different physicochemical parameters and their potential use as delivery systems in one tumor model. Therefore, to achieve therapeutic effect via nanocarrier with therapeutic agent, the properties of the developed NPs must be clearly defined. Herein, we report the development and modification of 99mTc and Cy5-labeled NPs based on calcium carbonate (CaCO3) and silica oxide (SiO2) to investigate in vitro and in vivo distribution on an example of a breast cancer model. We describe the synthesis and characterization of these NPs, including their morphology, size distribution, stability in biological media and cytotoxicity. Transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), direct radiometry analysis, and histology were used to collect all data. The cellular uptake of NPs on 4T1 cell linewas shown in vitro and in vivo. As a result, we demonstrated that these NPs are non-toxic, biocompatible, and stable system to use for delivery of bioactive compounds into breast cancer. |
| format | Article |
| id | doaj-art-5e4735df6aec45b0b128402c944f0785 |
| institution | Kabale University |
| issn | 2411-1414 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-5e4735df6aec45b0b128402c944f07852024-12-25T09:36:56ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142024-05-0111210.15826/chimtech.2024.11.2.125326Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targetingAlisa S. Postovalova0Yulia A. Tishchenko1Vladislava A. Rusakova2Timofey E. Karpov3Nina V. Gavrilova4Anna S. Rogova5Irina A. Gorbunova6Alexander S. Timin7ITMO University; Peter the Great St. Petersburg Polytechnic UniversityPeter the Great St. Petersburg Polytechnic University; St. Petersburg Academic UniversitySt. Petersburg Academic UniversityPeter the Great St. Petersburg Polytechnic UniversitySmorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation; Peter the Great St. Petersburg Polytechnic UniversityPeter the Great St. Petersburg Polytechnic UniversityITMO UniversityPeter the Great St. Petersburg Polytechnic UniversityNanoparticles (NPs) are widely used platforms for delivery of various biologically active compounds. Unfortunately, there is a lack of comprehensive investigations that would include a few types of NPs with different physicochemical parameters and their potential use as delivery systems in one tumor model. Therefore, to achieve therapeutic effect via nanocarrier with therapeutic agent, the properties of the developed NPs must be clearly defined. Herein, we report the development and modification of 99mTc and Cy5-labeled NPs based on calcium carbonate (CaCO3) and silica oxide (SiO2) to investigate in vitro and in vivo distribution on an example of a breast cancer model. We describe the synthesis and characterization of these NPs, including their morphology, size distribution, stability in biological media and cytotoxicity. Transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), direct radiometry analysis, and histology were used to collect all data. The cellular uptake of NPs on 4T1 cell linewas shown in vitro and in vivo. As a result, we demonstrated that these NPs are non-toxic, biocompatible, and stable system to use for delivery of bioactive compounds into breast cancer.https://chimicatechnoacta.ru/article/view/7695nanoparticlesinorganic materialsradiolabelingbreast cancerpassive delivery |
| spellingShingle | Alisa S. Postovalova Yulia A. Tishchenko Vladislava A. Rusakova Timofey E. Karpov Nina V. Gavrilova Anna S. Rogova Irina A. Gorbunova Alexander S. Timin Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting Chimica Techno Acta nanoparticles inorganic materials radiolabeling breast cancer passive delivery |
| title | Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting |
| title_full | Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting |
| title_fullStr | Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting |
| title_full_unstemmed | Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting |
| title_short | Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting |
| title_sort | inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting |
| topic | nanoparticles inorganic materials radiolabeling breast cancer passive delivery |
| url | https://chimicatechnoacta.ru/article/view/7695 |
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