Mucosal immune response in biology, disease prevention and treatment
Abstract The mucosal immune system, as the most extensive peripheral immune network, serves as the frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion and establishing immune tolerance. A comprehensive understanding of mucosal immunity...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-024-02043-4 |
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| _version_ | 1841544235166203904 |
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| author | Xiaoxue Zhou Yuchen Wu Zhipeng Zhu Chu Lu Chunwu Zhang Linghui Zeng Feng Xie Long Zhang Fangfang Zhou |
| author_facet | Xiaoxue Zhou Yuchen Wu Zhipeng Zhu Chu Lu Chunwu Zhang Linghui Zeng Feng Xie Long Zhang Fangfang Zhou |
| author_sort | Xiaoxue Zhou |
| collection | DOAJ |
| description | Abstract The mucosal immune system, as the most extensive peripheral immune network, serves as the frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion and establishing immune tolerance. A comprehensive understanding of mucosal immunity is essential for developing treatments that can effectively target diseases at their entry points, thereby minimizing the overall impact on the body. Despite its importance, our knowledge of mucosal immunity remains incomplete, necessitating further research. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has underscored the critical role of mucosal immunity in disease prevention and treatment. This systematic review focuses on the dynamic interactions between mucosa-associated lymphoid structures and related diseases. We delve into the basic structures and functions of these lymphoid tissues during disease processes and explore the intricate regulatory networks and mechanisms involved. Additionally, we summarize novel therapies and clinical research advances in the prevention of mucosal immunity-related diseases. The review also addresses the challenges in developing mucosal vaccines, which aim to induce specific immune responses while maintaining tolerance to non-pathogenic microbes. Innovative therapies, such as nanoparticle vaccines and inhalable antibodies, show promise in enhancing mucosal immunity and offer potential for improved disease prevention and treatment. |
| format | Article |
| id | doaj-art-5e0c6968e8404e02ac8da94e88f826c1 |
| institution | Kabale University |
| issn | 2059-3635 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj-art-5e0c6968e8404e02ac8da94e88f826c12025-01-12T12:41:36ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352025-01-0110113210.1038/s41392-024-02043-4Mucosal immune response in biology, disease prevention and treatmentXiaoxue Zhou0Yuchen Wu1Zhipeng Zhu2Chu Lu3Chunwu Zhang4Linghui Zeng5Feng Xie6Long Zhang7Fangfang Zhou8School of Medicine, Hangzhou City UniversityThe First School of Medicine, Wenzhou Medical UniversityMOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang UniversityThe First Affiliated Hospital, the Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow UniversityThe First School of Medicine, Wenzhou Medical UniversitySchool of Medicine, Hangzhou City UniversityThe First Affiliated Hospital, the Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow UniversityMOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang UniversityThe First Affiliated Hospital, the Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow UniversityAbstract The mucosal immune system, as the most extensive peripheral immune network, serves as the frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion and establishing immune tolerance. A comprehensive understanding of mucosal immunity is essential for developing treatments that can effectively target diseases at their entry points, thereby minimizing the overall impact on the body. Despite its importance, our knowledge of mucosal immunity remains incomplete, necessitating further research. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has underscored the critical role of mucosal immunity in disease prevention and treatment. This systematic review focuses on the dynamic interactions between mucosa-associated lymphoid structures and related diseases. We delve into the basic structures and functions of these lymphoid tissues during disease processes and explore the intricate regulatory networks and mechanisms involved. Additionally, we summarize novel therapies and clinical research advances in the prevention of mucosal immunity-related diseases. The review also addresses the challenges in developing mucosal vaccines, which aim to induce specific immune responses while maintaining tolerance to non-pathogenic microbes. Innovative therapies, such as nanoparticle vaccines and inhalable antibodies, show promise in enhancing mucosal immunity and offer potential for improved disease prevention and treatment.https://doi.org/10.1038/s41392-024-02043-4 |
| spellingShingle | Xiaoxue Zhou Yuchen Wu Zhipeng Zhu Chu Lu Chunwu Zhang Linghui Zeng Feng Xie Long Zhang Fangfang Zhou Mucosal immune response in biology, disease prevention and treatment Signal Transduction and Targeted Therapy |
| title | Mucosal immune response in biology, disease prevention and treatment |
| title_full | Mucosal immune response in biology, disease prevention and treatment |
| title_fullStr | Mucosal immune response in biology, disease prevention and treatment |
| title_full_unstemmed | Mucosal immune response in biology, disease prevention and treatment |
| title_short | Mucosal immune response in biology, disease prevention and treatment |
| title_sort | mucosal immune response in biology disease prevention and treatment |
| url | https://doi.org/10.1038/s41392-024-02043-4 |
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