In Silico and in vitro evaluation of the anticancer effect of a 1,5-Benzodiazepin-2-One derivative (3b) revealing potent dual inhibition of HER2 and HDAC1

In Silico and in vitro evaluation of the anticancer effect of a 1,5-Benzodiazepin-2-One derivative (3b) revealing potent dual inhibition of HER2 and HDAC1

Abstract Benzodiazepines are widely recognized for their therapeutic benefits in the treatment of anxiety and insomnia. However, in the pursuit of innovative anticancer agents, they have gained attention as a possible pharmacophore. One of those promising anticancer benzodiazepines is 3b which was d...

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Bibliographic Details
Main Authors: Nada S. Al-Theyab, Ahmad H. Bakheit, Sanae Lahmidi, Mohammed Mufadhe Alanazi, Awadh M Ali, Khalil Azzaoui, El Mokhtar Essassi, Joel T. Mague, Mohamad Hefnawy, Mohammed Mater Alanazi, Ashwag S. Alanazi
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Benzodiazepine
HDAC inhibitor, HER2 inhibitor
Cell cycle analysis
Programed cell death
Molecular dynamics simulations
Online Access:https://doi.org/10.1038/s41598-025-97786-7
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