A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes
Background: Tractography allows the in vivo study of subcortical white matter, and it is a potential tool for providing predictive indices on post-operative outcomes. We aim at establishing whether there is a relation between cognitive outcome and the status of the inferior fronto-occipital fascicul...
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2024-12-01
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| Series: | Current Oncology |
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| author | Barbara Tomasino Cinzia Baiano Giuseppe Kenneth Ricciardi Marta Maieron Andrea Romano Ilaria Guarracino Miriam Isola Maria De Martino Serena D’Agostini Daniele Bagatto Teresa Somma Miran Skrap Tamara Ius |
| author_facet | Barbara Tomasino Cinzia Baiano Giuseppe Kenneth Ricciardi Marta Maieron Andrea Romano Ilaria Guarracino Miriam Isola Maria De Martino Serena D’Agostini Daniele Bagatto Teresa Somma Miran Skrap Tamara Ius |
| author_sort | Barbara Tomasino |
| collection | DOAJ |
| description | Background: Tractography allows the in vivo study of subcortical white matter, and it is a potential tool for providing predictive indices on post-operative outcomes. We aim at establishing whether there is a relation between cognitive outcome and the status of the inferior fronto-occipital fasciculus’s (IFOF’s) microstructure. Methods: The longitudinal neuropsychological data of thirty young (median age: 35 years) patients operated on for DLGG in the left temporo-insular cortex along with pre-surgery tractography data were processed. Results: A degraded integrity of the left (vs. right) IFOF (lower fractional anisotropy and length, <i>p</i> < 0.001; higher mean and axial diffusivity, <i>p</i> < 0.01) was found, with lower microstructural variables in the infiltration (vs. dislocation) group. Significant decreases immediately post-surgery vs. pre-surgery mainly occurred in lexico-semantics (<i>p</i> < 0.001), with significant improvements at follow-up in all the tests (<i>p</i> < 0.01 to <i>p</i> < 0.001), despite values in the range of 44% to 47.82% of patients with below cut-off scores regarding naming verbs and making visual lexical decisions. The status of left and right IFOFs is predictive of a decrease in immediate post-surgery performance for several tests (<i>p</i> < 0.05); similarly, it is predictive of better recovery in the follow-up performance for naming nouns, naming verbs, making phonological fluency lexical decisions, and the token test (<i>p</i> < −0.05). For the ROC analysis, a significant result was obtained for the verb-naming test, with a cut-off of 79%. Conclusions: This study supports the role of the predictive value of pre-operative tractography for assessing the immediate post-operative result and at follow-up the risk of developing a cognitive deficit. |
| format | Article |
| id | doaj-art-5e032bb1dec8473690671e52a18d2b38 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Current Oncology |
| spelling | doaj-art-5e032bb1dec8473690671e52a18d2b382024-12-27T14:20:05ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-0131128075809310.3390/curroncol31120595A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive OutcomesBarbara Tomasino0Cinzia Baiano1Giuseppe Kenneth Ricciardi2Marta Maieron3Andrea Romano4Ilaria Guarracino5Miriam Isola6Maria De Martino7Serena D’Agostini8Daniele Bagatto9Teresa Somma10Miran Skrap11Tamara Ius12Scientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, 33037 Pasian di Prato, ItalyDivision of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, 80138 Napoli, ItalyNeuroradiology Departments, Azienda Ospedaliera Universitaria Integrata Verona, Ospedale Civile Maggiore, Borgo Trento, 37126 Verona, ItalyDepartment of Physics, University Hospital of Udine, 33100 Udine, ItalyNESMOS Department, U.O.C. Neuroradiology “Sant’Andrea” University Hospital, 00189 Rome, ItalyScientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, 33037 Pasian di Prato, ItalyDivision of Medical Statistic, Department of Medicine (DAME), University of Udine, 33100 Udine, ItalyDivision of Medical Statistic, Department of Medicine (DAME), University of Udine, 33100 Udine, ItalyNeuroradiology Unit, Department of Diagnostic Imaging, University Hospital of Udine, 33100 Udine, ItalyNeuroradiology Unit, Department of Diagnostic Imaging, University Hospital of Udine, 33100 Udine, ItalyDivision of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, 80138 Napoli, ItalyNeurosurgery Unit, Head-Neck and NeuroSciences Department University Hospital of Udine, 33100 Udine, ItalyNeurosurgery Unit, Head-Neck and NeuroSciences Department University Hospital of Udine, 33100 Udine, ItalyBackground: Tractography allows the in vivo study of subcortical white matter, and it is a potential tool for providing predictive indices on post-operative outcomes. We aim at establishing whether there is a relation between cognitive outcome and the status of the inferior fronto-occipital fasciculus’s (IFOF’s) microstructure. Methods: The longitudinal neuropsychological data of thirty young (median age: 35 years) patients operated on for DLGG in the left temporo-insular cortex along with pre-surgery tractography data were processed. Results: A degraded integrity of the left (vs. right) IFOF (lower fractional anisotropy and length, <i>p</i> < 0.001; higher mean and axial diffusivity, <i>p</i> < 0.01) was found, with lower microstructural variables in the infiltration (vs. dislocation) group. Significant decreases immediately post-surgery vs. pre-surgery mainly occurred in lexico-semantics (<i>p</i> < 0.001), with significant improvements at follow-up in all the tests (<i>p</i> < 0.01 to <i>p</i> < 0.001), despite values in the range of 44% to 47.82% of patients with below cut-off scores regarding naming verbs and making visual lexical decisions. The status of left and right IFOFs is predictive of a decrease in immediate post-surgery performance for several tests (<i>p</i> < 0.05); similarly, it is predictive of better recovery in the follow-up performance for naming nouns, naming verbs, making phonological fluency lexical decisions, and the token test (<i>p</i> < −0.05). For the ROC analysis, a significant result was obtained for the verb-naming test, with a cut-off of 79%. Conclusions: This study supports the role of the predictive value of pre-operative tractography for assessing the immediate post-operative result and at follow-up the risk of developing a cognitive deficit.https://www.mdpi.com/1718-7729/31/12/595predictive valuelower-grade gliomasinferior fronto-occipital fasciculusmicrostructure analysisfiber trackingneuropsychology |
| spellingShingle | Barbara Tomasino Cinzia Baiano Giuseppe Kenneth Ricciardi Marta Maieron Andrea Romano Ilaria Guarracino Miriam Isola Maria De Martino Serena D’Agostini Daniele Bagatto Teresa Somma Miran Skrap Tamara Ius A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes Current Oncology predictive value lower-grade gliomas inferior fronto-occipital fasciculus microstructure analysis fiber tracking neuropsychology |
| title | A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes |
| title_full | A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes |
| title_fullStr | A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes |
| title_full_unstemmed | A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes |
| title_short | A Longitudinal Multimodal Imaging Study in Patients with Temporo-Insular Diffuse Low-Grade Tumors: How the Inferior Fronto-Occipital Fasciculus Provides Information on Cognitive Outcomes |
| title_sort | longitudinal multimodal imaging study in patients with temporo insular diffuse low grade tumors how the inferior fronto occipital fasciculus provides information on cognitive outcomes |
| topic | predictive value lower-grade gliomas inferior fronto-occipital fasciculus microstructure analysis fiber tracking neuropsychology |
| url | https://www.mdpi.com/1718-7729/31/12/595 |
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