Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies
Aims To phenotype patients referred to a tertiary centre for the exploration of a left ventricular hypertrophy (LVH) starting from 12 mm of left ventricular wall thickness (LVWT).Methods and results Consecutive patients referred for aetiological workup of LVH, beginning at 12 mm of LVWT were retrosp...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021-02-01
|
| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/8/1/e001462.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846170525710155776 |
|---|---|
| author | Didier Carrié Stéphanie Brun Eve Cariou Michel Galinier Maxime Beneyto Jérémy Brunel Alex Scripcariu Hubert Delasnerie Delphine Dupin Deguine |
| author_facet | Didier Carrié Stéphanie Brun Eve Cariou Michel Galinier Maxime Beneyto Jérémy Brunel Alex Scripcariu Hubert Delasnerie Delphine Dupin Deguine |
| author_sort | Didier Carrié |
| collection | DOAJ |
| description | Aims To phenotype patients referred to a tertiary centre for the exploration of a left ventricular hypertrophy (LVH) starting from 12 mm of left ventricular wall thickness (LVWT).Methods and results Consecutive patients referred for aetiological workup of LVH, beginning at 12 mm of LVWT were retrospectively included in this tertiary single-centred observational study. Patients presenting with severe aortic stenosis were excluded. Aetiological workup was reviewed for each subject and aetiologies were adjudicated by expert consensus.Among 591 patients referred for LVH aetiological workup, 41% had a maximal LVWT below 15 mm. LVH aetiologies were led by cardiac amyloidosis (CA, 34.3%), followed by sarcomeric hypertrophic cardiomyopathy (S-HCM, 32.1%), hypertensive cardiomyopathy (21.7%), unknown aetiology (7.6%) and other (4.2%), including Anderson-Fabry’s disease (1.7%). CA and S-HCM affected over 50% of patients with mild LVH (12–14 mm); the prevalence of these aetiologies rose with LVH severity. Among patients with Anderson-Fabry’s disease, 4 (40%) had a maximal LVWT <15 mm.Conclusions Mild LVH (ie, 12–14 mm) conceals multiple aetiologies that can lead to specific treatment, cascade family screening and specific follow-up. Overall, CA is nowadays the leading cause of LVH in tertiary centers. |
| format | Article |
| id | doaj-art-5df97180b3f34686857eb5dbc7c8313a |
| institution | Kabale University |
| issn | 2053-3624 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj-art-5df97180b3f34686857eb5dbc7c8313a2024-11-11T19:15:08ZengBMJ Publishing GroupOpen Heart2053-36242021-02-018110.1136/openhrt-2020-001462Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologiesDidier Carrié0Stéphanie Brun1Eve Cariou2Michel Galinier3Maxime Beneyto4Jérémy Brunel5Alex Scripcariu6Hubert Delasnerie7Delphine Dupin Deguine8Cardiology, CHU Toulouse Pôle Cardiovasculaire et Métabolique, Toulouse, France1 Cardiology, University Hospital of Rangueil, Toulouse, FranceCardiology, CHU Toulouse Pôle Cardiovasculaire et Métabolique, Toulouse, FranceCardiology, CHU Toulouse Pôle Cardiovasculaire et Métabolique, Toulouse, FranceCardiology, CHU Toulouse Pôle Cardiovasculaire et Métabolique, Toulouse, FranceCardiology, CHU Toulouse Pôle Cardiovasculaire et Métabolique, Toulouse, FranceCardiology, CHU Toulouse Pôle Cardiovasculaire et Métabolique, Toulouse, FranceCardiology, CHU Toulouse Pôle Cardiovasculaire et Métabolique, Toulouse, FranceGenetics, CHU Toulouse, Toulouse, FranceAims To phenotype patients referred to a tertiary centre for the exploration of a left ventricular hypertrophy (LVH) starting from 12 mm of left ventricular wall thickness (LVWT).Methods and results Consecutive patients referred for aetiological workup of LVH, beginning at 12 mm of LVWT were retrospectively included in this tertiary single-centred observational study. Patients presenting with severe aortic stenosis were excluded. Aetiological workup was reviewed for each subject and aetiologies were adjudicated by expert consensus.Among 591 patients referred for LVH aetiological workup, 41% had a maximal LVWT below 15 mm. LVH aetiologies were led by cardiac amyloidosis (CA, 34.3%), followed by sarcomeric hypertrophic cardiomyopathy (S-HCM, 32.1%), hypertensive cardiomyopathy (21.7%), unknown aetiology (7.6%) and other (4.2%), including Anderson-Fabry’s disease (1.7%). CA and S-HCM affected over 50% of patients with mild LVH (12–14 mm); the prevalence of these aetiologies rose with LVH severity. Among patients with Anderson-Fabry’s disease, 4 (40%) had a maximal LVWT <15 mm.Conclusions Mild LVH (ie, 12–14 mm) conceals multiple aetiologies that can lead to specific treatment, cascade family screening and specific follow-up. Overall, CA is nowadays the leading cause of LVH in tertiary centers.https://openheart.bmj.com/content/8/1/e001462.full |
| spellingShingle | Didier Carrié Stéphanie Brun Eve Cariou Michel Galinier Maxime Beneyto Jérémy Brunel Alex Scripcariu Hubert Delasnerie Delphine Dupin Deguine Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies Open Heart |
| title | Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies |
| title_full | Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies |
| title_fullStr | Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies |
| title_full_unstemmed | Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies |
| title_short | Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies |
| title_sort | tip of the iceberg a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies |
| url | https://openheart.bmj.com/content/8/1/e001462.full |
| work_keys_str_mv | AT didiercarrie tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT stephaniebrun tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT evecariou tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT michelgalinier tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT maximebeneyto tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT jeremybrunel tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT alexscripcariu tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT hubertdelasnerie tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies AT delphinedupindeguine tipoftheicebergatertiarycarecentreretrospectivestudyofleftventricularhypertrophyaetiologies |