Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis
Background: Eosinophilic chronic rhinosinusitis (ECRS) is characterized by intense eosinophil infiltration in nasal polyps (NPs), related to asthma comorbidity and elevated circulating eosinophil levels. The mechanism by which these systemic components affect type 2 inflammation in NPs is poorly und...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-11-01
|
| Series: | Journal of Allergy and Clinical Immunology: Global |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325001511 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226863914778624 |
|---|---|
| author | Yuki Sonoda, MD Yoshimasa Imoto, MD, PhD Ayako Maegawa, MD Anna Shimizu, MD Masanori Kidoguchi, MD, PhD Rikako Gozawa, MD Keisuke Koyama, MD Naoto Adachi, MD Taiyo Morikawa, MD, PhD Yuto Miyazaki, MD Takahiro Tokunaga, MD, PhD Masafumi Sakashita, MD, PhD Shigeharu Ueki, MD, PhD Takechiyo Yamada, MD, PhD Shigeharu Fujieda, MD, PhD |
| author_facet | Yuki Sonoda, MD Yoshimasa Imoto, MD, PhD Ayako Maegawa, MD Anna Shimizu, MD Masanori Kidoguchi, MD, PhD Rikako Gozawa, MD Keisuke Koyama, MD Naoto Adachi, MD Taiyo Morikawa, MD, PhD Yuto Miyazaki, MD Takahiro Tokunaga, MD, PhD Masafumi Sakashita, MD, PhD Shigeharu Ueki, MD, PhD Takechiyo Yamada, MD, PhD Shigeharu Fujieda, MD, PhD |
| author_sort | Yuki Sonoda, MD |
| collection | DOAJ |
| description | Background: Eosinophilic chronic rhinosinusitis (ECRS) is characterized by intense eosinophil infiltration in nasal polyps (NPs), related to asthma comorbidity and elevated circulating eosinophil levels. The mechanism by which these systemic components affect type 2 inflammation in NPs is poorly understood. Objective: We sought to evaluate the relationship between lung function and eosinophilia in chronic rhinosinusitis and assess whether ECRS reflects lower airway involvement and systemic eosinophilic inflammation. Methods: We examined 198 patients with chronic rhinosinusitis. Lung function was assessed preoperatively using spirometry and fractional exhaled nitric oxide (Feno). Patients were classified into ECRS and non-ECRS groups on the basis of the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis score, and patients with odontogenic maxillary sinusitis (OMS) were included for comparison. mRNA expressions of inflammatory cytokines in NPs were measured by quantitative real-time PCR. Results: FEV1/forced vital capacity ratio, predicted FEV1/forced vital capacity, and predicted maximum midexpiratory flow were significantly lower in the ECRS group than in the non-ECRS and OMS groups. Feno levels were significantly higher in the ECRS group. The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis score correlated with lung function and Feno. Notably, some patients with ECRS showed impaired respiratory function and elevated Feno levels without a documented asthma diagnosis, suggesting possible undiagnosed asthma. Gene expression levels of type 2 cytokines in NPs were elevated in patients with ECRS and in those with peripheral eosinophilia greater than 5%. Conclusions: Respiratory function was significantly lower in patients with ECRS without an asthma diagnosis compared with non-ECRS and OMS groups. Enhanced eosinophilic inflammation in NPs may affect the lower airways, suggesting an eosinophilic united airway disease. |
| format | Article |
| id | doaj-art-5df82cd837524d10a4e3a44c30d31d7d |
| institution | Kabale University |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-5df82cd837524d10a4e3a44c30d31d7d2025-08-24T05:15:32ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-11-014410055010.1016/j.jacig.2025.100550Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitisYuki Sonoda, MD0Yoshimasa Imoto, MD, PhD1Ayako Maegawa, MD2Anna Shimizu, MD3Masanori Kidoguchi, MD, PhD4Rikako Gozawa, MD5Keisuke Koyama, MD6Naoto Adachi, MD7Taiyo Morikawa, MD, PhD8Yuto Miyazaki, MD9Takahiro Tokunaga, MD, PhD10Masafumi Sakashita, MD, PhD11Shigeharu Ueki, MD, PhD12Takechiyo Yamada, MD, PhD13Shigeharu Fujieda, MD, PhD14Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan; Corresponding author: Yoshimasa Imoto, MD, PhD, Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui 910-1193, Japan.Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of Otorhinolaryngology, Shinseikai Toyama Hospital, Toyama, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanDepartment of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Akita, Akita, JapanDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, JapanBackground: Eosinophilic chronic rhinosinusitis (ECRS) is characterized by intense eosinophil infiltration in nasal polyps (NPs), related to asthma comorbidity and elevated circulating eosinophil levels. The mechanism by which these systemic components affect type 2 inflammation in NPs is poorly understood. Objective: We sought to evaluate the relationship between lung function and eosinophilia in chronic rhinosinusitis and assess whether ECRS reflects lower airway involvement and systemic eosinophilic inflammation. Methods: We examined 198 patients with chronic rhinosinusitis. Lung function was assessed preoperatively using spirometry and fractional exhaled nitric oxide (Feno). Patients were classified into ECRS and non-ECRS groups on the basis of the Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis score, and patients with odontogenic maxillary sinusitis (OMS) were included for comparison. mRNA expressions of inflammatory cytokines in NPs were measured by quantitative real-time PCR. Results: FEV1/forced vital capacity ratio, predicted FEV1/forced vital capacity, and predicted maximum midexpiratory flow were significantly lower in the ECRS group than in the non-ECRS and OMS groups. Feno levels were significantly higher in the ECRS group. The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis score correlated with lung function and Feno. Notably, some patients with ECRS showed impaired respiratory function and elevated Feno levels without a documented asthma diagnosis, suggesting possible undiagnosed asthma. Gene expression levels of type 2 cytokines in NPs were elevated in patients with ECRS and in those with peripheral eosinophilia greater than 5%. Conclusions: Respiratory function was significantly lower in patients with ECRS without an asthma diagnosis compared with non-ECRS and OMS groups. Enhanced eosinophilic inflammation in NPs may affect the lower airways, suggesting an eosinophilic united airway disease.http://www.sciencedirect.com/science/article/pii/S2772829325001511Eosinophilic chronic rhinosinusitislung functioneosinophilstype 2 cytokinesasthmanasal polyps |
| spellingShingle | Yuki Sonoda, MD Yoshimasa Imoto, MD, PhD Ayako Maegawa, MD Anna Shimizu, MD Masanori Kidoguchi, MD, PhD Rikako Gozawa, MD Keisuke Koyama, MD Naoto Adachi, MD Taiyo Morikawa, MD, PhD Yuto Miyazaki, MD Takahiro Tokunaga, MD, PhD Masafumi Sakashita, MD, PhD Shigeharu Ueki, MD, PhD Takechiyo Yamada, MD, PhD Shigeharu Fujieda, MD, PhD Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis Journal of Allergy and Clinical Immunology: Global Eosinophilic chronic rhinosinusitis lung function eosinophils type 2 cytokines asthma nasal polyps |
| title | Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis |
| title_full | Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis |
| title_fullStr | Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis |
| title_full_unstemmed | Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis |
| title_short | Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis |
| title_sort | lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis |
| topic | Eosinophilic chronic rhinosinusitis lung function eosinophils type 2 cytokines asthma nasal polyps |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325001511 |
| work_keys_str_mv | AT yukisonodamd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT yoshimasaimotomdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT ayakomaegawamd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT annashimizumd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT masanorikidoguchimdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT rikakogozawamd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT keisukekoyamamd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT naotoadachimd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT taiyomorikawamdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT yutomiyazakimd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT takahirotokunagamdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT masafumisakashitamdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT shigeharuuekimdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT takechiyoyamadamdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis AT shigeharufujiedamdphd lungfunctionimpairmentandeosinophiliainpatientswitheosinophilicchronicrhinosinusitis |