ABO blood group and the risk of aortic disease: a nationwide cohort study
Objectives To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden.Design This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between A...
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| Format: | Article |
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BMJ Publishing Group
2020-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/10/e036040.full |
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| author | Gustaf Edgren Shahab Nozohoor Igor Zindovic Ammar Majeed |
| author_facet | Gustaf Edgren Shahab Nozohoor Igor Zindovic Ammar Majeed |
| author_sort | Gustaf Edgren |
| collection | DOAJ |
| description | Objectives To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden.Design This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs).Setting Swedish population-based study.Participants The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years.Primary and secondary outcome measures IRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group.Results A total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93–1.04) and 1.00 (95% CI, 0.97–1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85–0.96).Conclusions In the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation. |
| format | Article |
| id | doaj-art-5dedab50fac24174a8fe4ae739195c68 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-5dedab50fac24174a8fe4ae739195c682024-11-16T19:40:08ZengBMJ Publishing GroupBMJ Open2044-60552020-10-01101010.1136/bmjopen-2019-036040ABO blood group and the risk of aortic disease: a nationwide cohort studyGustaf Edgren0Shahab Nozohoor1Igor Zindovic2Ammar Majeed3Department of Medicine, Solna, Karolinska Institutet, Stockholm, SwedenDepartment of Clinical Sciences Lund, Department of Cardiothoracic Surgery, Skåne University Hospital Lund, Lund University, Lund, SwedenDepartment of Clinical Sciences Lund, Department of Cardiothoracic Surgery, Skåne University Hospital Lund, Lund University, Lund, SwedenDepartment of Medicine, Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, SwedenObjectives To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden.Design This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs).Setting Swedish population-based study.Participants The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years.Primary and secondary outcome measures IRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group.Results A total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93–1.04) and 1.00 (95% CI, 0.97–1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85–0.96).Conclusions In the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation.https://bmjopen.bmj.com/content/10/10/e036040.full |
| spellingShingle | Gustaf Edgren Shahab Nozohoor Igor Zindovic Ammar Majeed ABO blood group and the risk of aortic disease: a nationwide cohort study BMJ Open |
| title | ABO blood group and the risk of aortic disease: a nationwide cohort study |
| title_full | ABO blood group and the risk of aortic disease: a nationwide cohort study |
| title_fullStr | ABO blood group and the risk of aortic disease: a nationwide cohort study |
| title_full_unstemmed | ABO blood group and the risk of aortic disease: a nationwide cohort study |
| title_short | ABO blood group and the risk of aortic disease: a nationwide cohort study |
| title_sort | abo blood group and the risk of aortic disease a nationwide cohort study |
| url | https://bmjopen.bmj.com/content/10/10/e036040.full |
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