ABO blood group and the risk of aortic disease: a nationwide cohort study
Objectives To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden.Design This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between A...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-10-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/10/e036040.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Objectives To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden.Design This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and presented as incidence rate ratios (IRRs).Setting Swedish population-based study.Participants The study cohort consisted of 1 164 561 Swedish blood donors and 961 637 transfused patients with a combined follow-up time of 29 390 649 person-years.Primary and secondary outcome measures IRRs of aortic events (ie, aortic aneurysms and/or aortic dissections) in relation to patient blood group.Results A total of 20 684 aortic events occurred during the study period. Non-O donors and patients had similar incidence of aortic events when compared with blood group O donors and patients with an IRR of 0.98 (95% CI, 0.93–1.04) and 1.00 (95% CI, 0.97–1.03), respectively. There were no differences between non-O and blood group O individuals when aortic dissections and aortic aneurysms were analysed separately. Blood group B conferred a lower risk of aortic aneurysms in the patient cohort when compared with blood group O (IRR, 0.90; 95% CI, 0.85–0.96).Conclusions In the present study, there were no statistically significant associations between ABO blood group and the risk of aortic disease. A possible protective effect of blood group B was observed in the patient cohort but this finding requires further investigation. |
|---|---|
| ISSN: | 2044-6055 |