Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review
The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) remains unclear; however, emerging evidence suggests that mitochondrial injury plays a significant role. This review aims to elucidate the involvement of mitochondrial dysfunction in SONFH and explore potential therape...
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Bioscientifica
2024-11-01
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| Series: | EFORT Open Reviews |
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| Online Access: | https://eor.bioscientifica.com/view/journals/eor/9/11/EOR-24-0023.xml |
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| author | Yidan Yang Yi Jian Youwen Liu Maoxiao Ma Jiayi Guo Bin Xu Chen Yue |
| author_facet | Yidan Yang Yi Jian Youwen Liu Maoxiao Ma Jiayi Guo Bin Xu Chen Yue |
| author_sort | Yidan Yang |
| collection | DOAJ |
| description | The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) remains unclear; however, emerging evidence suggests that mitochondrial injury plays a significant role.
This review aims to elucidate the involvement of mitochondrial dysfunction in SONFH and explore potential therapeutic targets.
A comprehensive literature search was conducted in PubMed, Web of Science, and Elsevier ScienceDirect, focusing on mitochondrial homeostasis, including mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and oxidative stress in SONFH. Ultimately, we included and analyzed a total of 16 studies.
Glucocorticoids initially promote but later inhibit mitochondrial biogenesis in osteoblasts, leading to excessive ROS production and mitochondrial dysfunction. This dysfunction impairs osteoblast survival and bone formation, contributing to SONFH progression.
Key proteins such as mitochondrial transcription factor A (TFAM) and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1α) are potential therapeutic targets for promoting mitochondrial biogenesis and reducing ROS-induced damage.
Enhancing mitochondrial function and reducing oxidative stress in osteoblasts may prevent or slow the progression of SONFH. Future research should focus on developing these strategies. |
| format | Article |
| id | doaj-art-5dcd40ef3d4d42d9ab4ee43fadca744f |
| institution | Kabale University |
| issn | 2058-5241 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | EFORT Open Reviews |
| spelling | doaj-art-5dcd40ef3d4d42d9ab4ee43fadca744f2024-11-11T06:49:58ZengBioscientificaEFORT Open Reviews2058-52412024-11-0191110131022https://doi.org/10.1530/EOR-24-0023Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative reviewYidan Yang0Yi Jian1Youwen Liu2Maoxiao Ma3Jiayi Guo4Bin Xu5Chen Yue6Henan University of Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of ChinaDepartment of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of ChinaHenan University of Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of China; Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of ChinaHenan University of Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of China; Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, People’s Republic of ChinaDepartment of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) remains unclear; however, emerging evidence suggests that mitochondrial injury plays a significant role. This review aims to elucidate the involvement of mitochondrial dysfunction in SONFH and explore potential therapeutic targets. A comprehensive literature search was conducted in PubMed, Web of Science, and Elsevier ScienceDirect, focusing on mitochondrial homeostasis, including mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and oxidative stress in SONFH. Ultimately, we included and analyzed a total of 16 studies. Glucocorticoids initially promote but later inhibit mitochondrial biogenesis in osteoblasts, leading to excessive ROS production and mitochondrial dysfunction. This dysfunction impairs osteoblast survival and bone formation, contributing to SONFH progression. Key proteins such as mitochondrial transcription factor A (TFAM) and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1α) are potential therapeutic targets for promoting mitochondrial biogenesis and reducing ROS-induced damage. Enhancing mitochondrial function and reducing oxidative stress in osteoblasts may prevent or slow the progression of SONFH. Future research should focus on developing these strategies. https://eor.bioscientifica.com/view/journals/eor/9/11/EOR-24-0023.xmlmitochondria dynamicsmitochondrial homeostasismitophagysteroid-induced osteonecrosis of the femoral head |
| spellingShingle | Yidan Yang Yi Jian Youwen Liu Maoxiao Ma Jiayi Guo Bin Xu Chen Yue Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review EFORT Open Reviews mitochondria dynamics mitochondrial homeostasis mitophagy steroid-induced osteonecrosis of the femoral head |
| title | Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review |
| title_full | Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review |
| title_fullStr | Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review |
| title_full_unstemmed | Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review |
| title_short | Mitochondrial maintenance as a novel target for treating steroid-induced osteonecrosis of femoral head: a narrative review |
| title_sort | mitochondrial maintenance as a novel target for treating steroid induced osteonecrosis of femoral head a narrative review |
| topic | mitochondria dynamics mitochondrial homeostasis mitophagy steroid-induced osteonecrosis of the femoral head |
| url | https://eor.bioscientifica.com/view/journals/eor/9/11/EOR-24-0023.xml |
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