White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study
Abstract Aim To explore white matter (WM) tracts linked to impulsivity using the diffusion magnetic resonance imaging (DMRI) connectometry method. Methods We analyzed 218 healthy participants from the Leipzig Study for Mind‐Body‐Emotion Interactions database. Impulsivity correlations with DMRI‐deriv...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | PCN Reports |
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| Online Access: | https://doi.org/10.1002/pcn5.70018 |
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| author | Fatemeh Rashidi Mohammadamin Parsaei Iman Kiani Arash Sadri Mohammad Hadi Aarabi Seyed Reza Darijani Yune Sang Lee Hossein Sanjari Moghaddam |
| author_facet | Fatemeh Rashidi Mohammadamin Parsaei Iman Kiani Arash Sadri Mohammad Hadi Aarabi Seyed Reza Darijani Yune Sang Lee Hossein Sanjari Moghaddam |
| author_sort | Fatemeh Rashidi |
| collection | DOAJ |
| description | Abstract Aim To explore white matter (WM) tracts linked to impulsivity using the diffusion magnetic resonance imaging (DMRI) connectometry method. Methods We analyzed 218 healthy participants from the Leipzig Study for Mind‐Body‐Emotion Interactions database. Impulsivity correlations with DMRI‐derived WM changes were assessed using Urgency‐Premeditation‐Perseverance‐Sensation (UPPS) Impulsive Behavior Scale subscales: lack of perseverance (PE), lack of premeditation (PM), sensation seeking (SS), and negative urgency. DMRI data were processed using connectometry, adjusting for sex and age, to examine WM tract integrity via quantitative anisotropy (QA). Also, two additional interaction analyses were conducted to separately examine the interaction effect between WM QA, and sex and age in predicting impulsive behavior scores. The significance level in our statistical analyses was set at a false discovery rate (FDR) below 0.05. Results QA in the bilateral cerebellum and middle cerebellar peduncle showed a negative association with PE and PM severity (FDR = 0.0004). QA in the middle cerebellar peduncle, corpus callosum body, and forceps major demonstrated a positive association with SS (FDR = 0.0001). Conversely, QA in forceps minor had a positive association with PM (FDR = 0.004), and QA in forceps minor and bilateral cingulum showed a positive association with SS (FDR = 0.0005). Age and sex had no significant effects on the association between WM QA and UPPS subscale scores. Conclusion Impulsivity is linked to distinct WM integrity changes in various tracts, including the corpus callosum, cerebellum, and cingulum, offering insights into the pathophysiology of impulsivity and guiding future research. |
| format | Article |
| id | doaj-art-5db42f6eed3b4b48866b2028d1c2f14d |
| institution | Kabale University |
| issn | 2769-2558 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj-art-5db42f6eed3b4b48866b2028d1c2f14d2025-01-03T11:15:26ZengWileyPCN Reports2769-25582024-12-0134n/an/a10.1002/pcn5.70018White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging studyFatemeh Rashidi0Mohammadamin Parsaei1Iman Kiani2Arash Sadri3Mohammad Hadi Aarabi4Seyed Reza Darijani5Yune Sang Lee6Hossein Sanjari Moghaddam7School of Medicine Tehran University of Medical Sciences Tehran IranBreastfeeding Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran IranSchool of Medicine Tehran University of Medical Sciences Tehran IranLyceum Scientific Charity Tehran IranDepartment of Neuroscience University of Padova Padova ItalySchool of Medicine Tehran University of Medical Sciences Tehran IranSchool of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas USAPsychiatric Research Center, Roozbeh Hospital Tehran University of Medical Sciences Tehran IranAbstract Aim To explore white matter (WM) tracts linked to impulsivity using the diffusion magnetic resonance imaging (DMRI) connectometry method. Methods We analyzed 218 healthy participants from the Leipzig Study for Mind‐Body‐Emotion Interactions database. Impulsivity correlations with DMRI‐derived WM changes were assessed using Urgency‐Premeditation‐Perseverance‐Sensation (UPPS) Impulsive Behavior Scale subscales: lack of perseverance (PE), lack of premeditation (PM), sensation seeking (SS), and negative urgency. DMRI data were processed using connectometry, adjusting for sex and age, to examine WM tract integrity via quantitative anisotropy (QA). Also, two additional interaction analyses were conducted to separately examine the interaction effect between WM QA, and sex and age in predicting impulsive behavior scores. The significance level in our statistical analyses was set at a false discovery rate (FDR) below 0.05. Results QA in the bilateral cerebellum and middle cerebellar peduncle showed a negative association with PE and PM severity (FDR = 0.0004). QA in the middle cerebellar peduncle, corpus callosum body, and forceps major demonstrated a positive association with SS (FDR = 0.0001). Conversely, QA in forceps minor had a positive association with PM (FDR = 0.004), and QA in forceps minor and bilateral cingulum showed a positive association with SS (FDR = 0.0005). Age and sex had no significant effects on the association between WM QA and UPPS subscale scores. Conclusion Impulsivity is linked to distinct WM integrity changes in various tracts, including the corpus callosum, cerebellum, and cingulum, offering insights into the pathophysiology of impulsivity and guiding future research.https://doi.org/10.1002/pcn5.70018connectometrydiffusion magnetic resonance imagingimpulsive behaviorimpulsivity |
| spellingShingle | Fatemeh Rashidi Mohammadamin Parsaei Iman Kiani Arash Sadri Mohammad Hadi Aarabi Seyed Reza Darijani Yune Sang Lee Hossein Sanjari Moghaddam White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study PCN Reports connectometry diffusion magnetic resonance imaging impulsive behavior impulsivity |
| title | White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study |
| title_full | White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study |
| title_fullStr | White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study |
| title_full_unstemmed | White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study |
| title_short | White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study |
| title_sort | white matter correlates of impulsive behavior in healthy individuals a diffusion magnetic resonance imaging study |
| topic | connectometry diffusion magnetic resonance imaging impulsive behavior impulsivity |
| url | https://doi.org/10.1002/pcn5.70018 |
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