Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation
Abstract Central body fat distribution affects kidney function. Abdominal fat measurements using computed tomography (CT) may prove superior in assessing body composition-related kidney risk in living kidney donors. This retrospective cohort study including 550 kidney donors aimed to determine the a...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83320-8 |
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| author | Lisa B. Westenberg Marco van Londen Marcel Zorgdrager Mara A. McAdams-DeMarco Dorry L. Segev Stephan J. L. Bakker Alain R. Viddeleer Robert A. Pol |
| author_facet | Lisa B. Westenberg Marco van Londen Marcel Zorgdrager Mara A. McAdams-DeMarco Dorry L. Segev Stephan J. L. Bakker Alain R. Viddeleer Robert A. Pol |
| author_sort | Lisa B. Westenberg |
| collection | DOAJ |
| description | Abstract Central body fat distribution affects kidney function. Abdominal fat measurements using computed tomography (CT) may prove superior in assessing body composition-related kidney risk in living kidney donors. This retrospective cohort study including 550 kidney donors aimed to determine the association between CT-measured abdominal fat areas and kidney function before and after donor nephrectomy. Donors underwent glomerular filtration rate measurements (125I-Iothalamate, mGFR) before and 3 months after donation. Linear regression analyses with body surface area (BSA)-standardized and crude mGFR were performed to assess the association of height-indexed tomographic fat measurements with kidney function. In age-, and sex-adjusted analyses higher levels of total abdominal, visceral, subcutaneous, and intramuscular adipose tissue index were significantly associated with lower mGFR levels before donation (BSA-standardized mGFR: visceral adipose tissue index: Βeta=-0.11, p < 0.001, subcutaneous: Βeta=-0.10, p < 0.001, intramuscular: Βeta=-1.18, p < 0.001, total abdominal: Βeta=-0.07, p < 0.001). Higher tomographic abdominal fat is associated with lower BSA-standardized mGFR after donation and a greater decrease in mGFR between screening and 3 months post-donation. This study shows that CT-measured abdominal fat area is associated with kidney function before and after living kidney donation. |
| format | Article |
| id | doaj-art-5db25defde9041de9404ec039ae4e7a6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-5db25defde9041de9404ec039ae4e7a62024-12-29T12:26:49ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-83320-8Higher abdominal fat area associates with lower donor kidney function before and after living kidney donationLisa B. Westenberg0Marco van Londen1Marcel Zorgdrager2Mara A. McAdams-DeMarco3Dorry L. Segev4Stephan J. L. Bakker5Alain R. Viddeleer6Robert A. Pol7Department of Surgery, Division of Transplant Surgery, University Medical Center Groningen, University of GroningenDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of GroningenDepartment of Radiology, Medical Imaging Center, University Medical Center Groningen, University of GroningenDepartment of Surgery, New York University Langone HealthDepartment of Surgery, New York University Langone HealthDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of GroningenDepartment of Radiology, Medical Imaging Center, University Medical Center Groningen, University of GroningenDepartment of Surgery, Division of Transplant Surgery, University Medical Center Groningen, University of GroningenAbstract Central body fat distribution affects kidney function. Abdominal fat measurements using computed tomography (CT) may prove superior in assessing body composition-related kidney risk in living kidney donors. This retrospective cohort study including 550 kidney donors aimed to determine the association between CT-measured abdominal fat areas and kidney function before and after donor nephrectomy. Donors underwent glomerular filtration rate measurements (125I-Iothalamate, mGFR) before and 3 months after donation. Linear regression analyses with body surface area (BSA)-standardized and crude mGFR were performed to assess the association of height-indexed tomographic fat measurements with kidney function. In age-, and sex-adjusted analyses higher levels of total abdominal, visceral, subcutaneous, and intramuscular adipose tissue index were significantly associated with lower mGFR levels before donation (BSA-standardized mGFR: visceral adipose tissue index: Βeta=-0.11, p < 0.001, subcutaneous: Βeta=-0.10, p < 0.001, intramuscular: Βeta=-1.18, p < 0.001, total abdominal: Βeta=-0.07, p < 0.001). Higher tomographic abdominal fat is associated with lower BSA-standardized mGFR after donation and a greater decrease in mGFR between screening and 3 months post-donation. This study shows that CT-measured abdominal fat area is associated with kidney function before and after living kidney donation.https://doi.org/10.1038/s41598-024-83320-8living kidney donorabdominal fat tissuecomputed tomographykidney function |
| spellingShingle | Lisa B. Westenberg Marco van Londen Marcel Zorgdrager Mara A. McAdams-DeMarco Dorry L. Segev Stephan J. L. Bakker Alain R. Viddeleer Robert A. Pol Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation Scientific Reports living kidney donor abdominal fat tissue computed tomography kidney function |
| title | Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation |
| title_full | Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation |
| title_fullStr | Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation |
| title_full_unstemmed | Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation |
| title_short | Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation |
| title_sort | higher abdominal fat area associates with lower donor kidney function before and after living kidney donation |
| topic | living kidney donor abdominal fat tissue computed tomography kidney function |
| url | https://doi.org/10.1038/s41598-024-83320-8 |
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