Systemic evaluation of various CRISPR/Cas13 orthologs for knockdown of targeted transcripts in plants

Systemic evaluation of various CRISPR/Cas13 orthologs for knockdown of targeted transcripts in plants

Abstract Background CRISPR/Cas13 system, recognized for its compact size and specificity in targeting RNA, is currently employed for RNA degradation. However, the potential of various CRISPR/Cas13 subtypes, particularly concerning the knockdown of endogenous transcripts, remains to be comprehensivel...

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Bibliographic Details
Main Authors: Lu Yu, Jiawei Zou, Amjad Hussain, Ruoyu Jia, Yibo Fan, Jinhang Liu, Xinhui Nie, Xianlong Zhang, Shuangxia Jin
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Subjects:
Plants
CRISPR/Cas13 orthologs
RNA targeting
Transcript decay (gene knockdown)
RNA virus interference
Online Access:https://doi.org/10.1186/s13059-024-03448-8
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https://doi.org/10.1186/s13059-024-03448-8

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