Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome
As a highly effective immunosuppressant, tacrolimus（TAC,FK506）has been widely applied for primary nephrotic syndrome.However, excessive dose or underexposure of TAC remains rampant in clinical practices.Recent studies have indicated that cytochrome P450 family 3 subfamily A4（CYP3 A4）,cytochrome P450...
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57903734&Fpath=home&index=0 |
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| _version_ | 1849313219685908480 |
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| author | Xiong Lian-lian Yi Bin |
| author_facet | Xiong Lian-lian Yi Bin |
| author_sort | Xiong Lian-lian |
| collection | DOAJ |
| description | As a highly effective immunosuppressant, tacrolimus（TAC,FK506）has been widely applied for primary nephrotic syndrome.However, excessive dose or underexposure of TAC remains rampant in clinical practices.Recent studies have indicated that cytochrome P450 family 3 subfamily A4（CYP3 A4）,cytochrome P450 family 3 subfamily A5（CYP3 A5）metabolic enzymes and ABC transporter play important roles in its metabolisms and transports and single nucleotide gene polymorphisms may partially explain differences in pharmacokinetic profiles among individuals.This review summarized the effects of CYP3 A4/3 A5 and ABC transporter gene polymorphisms on TAC plasma concentrations in patients with primary nephrotic syndrome.It was intended as a theoretical basis for individualized treatment of TAC in this population. |
| format | Article |
| id | doaj-art-5dac2171ff7c48cd9c0ff8e14f788af9 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-5dac2171ff7c48cd9c0ff8e14f788af92025-08-20T03:52:51ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-0141642157903734Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndromeXiong Lian-lianYi BinAs a highly effective immunosuppressant, tacrolimus（TAC,FK506）has been widely applied for primary nephrotic syndrome.However, excessive dose or underexposure of TAC remains rampant in clinical practices.Recent studies have indicated that cytochrome P450 family 3 subfamily A4（CYP3 A4）,cytochrome P450 family 3 subfamily A5（CYP3 A5）metabolic enzymes and ABC transporter play important roles in its metabolisms and transports and single nucleotide gene polymorphisms may partially explain differences in pharmacokinetic profiles among individuals.This review summarized the effects of CYP3 A4/3 A5 and ABC transporter gene polymorphisms on TAC plasma concentrations in patients with primary nephrotic syndrome.It was intended as a theoretical basis for individualized treatment of TAC in this population.http://www.lcszb.com/thesisDetails?columnId=57903734&Fpath=home&index=0Tacrolimus binding proteinsGenetic polymorphismPrimary nephrotic syndrome |
| spellingShingle | Xiong Lian-lian Yi Bin Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome Linchuang shenzangbing zazhi Tacrolimus binding proteins Genetic polymorphism Primary nephrotic syndrome |
| title | Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome |
| title_full | Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome |
| title_fullStr | Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome |
| title_full_unstemmed | Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome |
| title_short | Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome |
| title_sort | effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome |
| topic | Tacrolimus binding proteins Genetic polymorphism Primary nephrotic syndrome |
| url | http://www.lcszb.com/thesisDetails?columnId=57903734&Fpath=home&index=0 |
| work_keys_str_mv | AT xionglianlian effectofgeneticpolymorphismonindividualizedtreatmentoftacrolimusinpatientswithprimarynephroticsyndrome AT yibin effectofgeneticpolymorphismonindividualizedtreatmentoftacrolimusinpatientswithprimarynephroticsyndrome |