Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment
Golgi Protein 73 (GP73) is a Golgi-resident protein that is highly expressed in primary tumor tissues. Initially identified as an oncoprotein, GP73 has been shown to promote tumor development, particularly by mediating the transport of proteins related to epithelial-mesenchymal transition (EMT), thu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1508034/full |
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| author | Pingping Feng Pingping Feng Xinyang Hu Xinyang Hu Sining Zhou Xianyong Liu Linghui Zeng Yiming Liu Yiming Liu Yiming Liu Yiming Liu |
| author_facet | Pingping Feng Pingping Feng Xinyang Hu Xinyang Hu Sining Zhou Xianyong Liu Linghui Zeng Yiming Liu Yiming Liu Yiming Liu Yiming Liu |
| author_sort | Pingping Feng |
| collection | DOAJ |
| description | Golgi Protein 73 (GP73) is a Golgi-resident protein that is highly expressed in primary tumor tissues. Initially identified as an oncoprotein, GP73 has been shown to promote tumor development, particularly by mediating the transport of proteins related to epithelial-mesenchymal transition (EMT), thus facilitating tumor cell EMT. Though our previous review has summarized the functional roles of GP73 in intracellular signal transduction and its various mechanisms in promoting EMT, recent studies have revealed that GP73 plays a crucial role in regulating the tumor and immune microenvironment. GP73 can modulate intracellular signaling pathways to influence cytokine and chemokine networks, resulting in inflammation caused by viral and bacterial infection or immune diseases, and leading tumor microenvironment deteriorated. Additionally, extracellular GP73 can also regulate signaling pathways of target cells by binding to their cell-surface receptors or entering the acceptor cells, thereby facilitating inflammation or promoting tumor development. In this review, we aim to summarize the findings, providing insights for future investigations on GP73 and its potential as a therapeutic target in ameliorating chronic inflammation in the immune and tumor microenvironment. |
| format | Article |
| id | doaj-art-5da5fc39a21249b8bcf323f9a730fb3a |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-5da5fc39a21249b8bcf323f9a730fb3a2025-01-08T05:10:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15080341508034Golgi protein 73: the driver of inflammation in the immune and tumor microenvironmentPingping Feng0Pingping Feng1Xinyang Hu2Xinyang Hu3Sining Zhou4Xianyong Liu5Linghui Zeng6Yiming Liu7Yiming Liu8Yiming Liu9Yiming Liu10Hangzhou Lin’an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University School of Medicine, Hangzhou, ChinaLaboratory of Cancer Biology, Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCancer Center, Zhejiang University, Hangzhou, ChinaLife Sciences Institute, Zhejiang University, Hangzhou, ChinaHangzhou Lin’an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University School of Medicine, Hangzhou, ChinaHangzhou Lin’an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University School of Medicine, Hangzhou, ChinaLaboratory of Cancer Biology, Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCancer Center, Zhejiang University, Hangzhou, ChinaGolgi Protein 73 (GP73) is a Golgi-resident protein that is highly expressed in primary tumor tissues. Initially identified as an oncoprotein, GP73 has been shown to promote tumor development, particularly by mediating the transport of proteins related to epithelial-mesenchymal transition (EMT), thus facilitating tumor cell EMT. Though our previous review has summarized the functional roles of GP73 in intracellular signal transduction and its various mechanisms in promoting EMT, recent studies have revealed that GP73 plays a crucial role in regulating the tumor and immune microenvironment. GP73 can modulate intracellular signaling pathways to influence cytokine and chemokine networks, resulting in inflammation caused by viral and bacterial infection or immune diseases, and leading tumor microenvironment deteriorated. Additionally, extracellular GP73 can also regulate signaling pathways of target cells by binding to their cell-surface receptors or entering the acceptor cells, thereby facilitating inflammation or promoting tumor development. In this review, we aim to summarize the findings, providing insights for future investigations on GP73 and its potential as a therapeutic target in ameliorating chronic inflammation in the immune and tumor microenvironment.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1508034/fullGolgi protein 73inflammationcytokine and chemokine networksanti-infection immunitytumor microenvironment |
| spellingShingle | Pingping Feng Pingping Feng Xinyang Hu Xinyang Hu Sining Zhou Xianyong Liu Linghui Zeng Yiming Liu Yiming Liu Yiming Liu Yiming Liu Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment Frontiers in Immunology Golgi protein 73 inflammation cytokine and chemokine networks anti-infection immunity tumor microenvironment |
| title | Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment |
| title_full | Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment |
| title_fullStr | Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment |
| title_full_unstemmed | Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment |
| title_short | Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment |
| title_sort | golgi protein 73 the driver of inflammation in the immune and tumor microenvironment |
| topic | Golgi protein 73 inflammation cytokine and chemokine networks anti-infection immunity tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1508034/full |
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