Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling

Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling

Abstract Point mutations in the ligand binding domain of retinoic acid receptor alpha (RARα) are linked to breast fibroepithelial tumor development, but their role in solid tumorigenesis is unclear. In this study, we assessed the functional effects of known RARα mutations on retinoic acid signaling...

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Main Authors: Xi Xiao Huang, Ley Moy Ng, Po-Hsien Lee, Peiyong Guan, Mun Juinn Chow, Aisyah Binte Mohamed Bashir, Meina Lau, Kenric Yi Shu Tan, Zhimei Li, Jason Yongsheng Chan, Jing Han Hong, Sheng Rong Ng, Tun Kiat Ko, Hong Lee Heng, Hsiang Ling Teo, Daniela Rhodes, Patrick Tan, Puay Hoon Tan, Donald P. McDonnell, Bin Tean Teh
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-024-00716-5
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