Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a review
Cancer is among the leading causes of mortality across the globe. Despite the development of wide variety of oncotherapeutics, the effectiveness of oncotherapeutic drugs and anti-cancer bioactive compounds is frequently hindered by their low solubility and poor bioavailability, highlighting the need...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925001525 |
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| author | Wanjie Zhang Shuwei Zhang Xiaojie Li Yan Qin Tan |
| author_facet | Wanjie Zhang Shuwei Zhang Xiaojie Li Yan Qin Tan |
| author_sort | Wanjie Zhang |
| collection | DOAJ |
| description | Cancer is among the leading causes of mortality across the globe. Despite the development of wide variety of oncotherapeutics, the effectiveness of oncotherapeutic drugs and anti-cancer bioactive compounds is frequently hindered by their low solubility and poor bioavailability, highlighting the need for efficient drug delivery system. Cyclodextrin (CD), a cyclic oligosaccharide produced by amylase hydrolysis of starch has emerged as promising candidates for drug delivery system due to their unique properties and low toxicity profile. This review comprehensively discussed the structure and properties of CD and its derivatives, as well as elucidated the synthesis and characterization of different types of CD-based drug delivery system including inclusion complex, nanoparticles, nanosponges, nanofibers, micelles, liposomes and hydrogels. The application of CD-based drug delivery system for oncotherapeutics was discussed and a forward-looking perspective on the challenges and prospects of CD-based drug delivery system demonstrated. |
| format | Article |
| id | doaj-art-5d810b8f4573404d8dcbc36a58ea32f5 |
| institution | Kabale University |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-5d810b8f4573404d8dcbc36a58ea32f52025-08-20T03:45:10ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-06-011010081410.1016/j.carpta.2025.100814Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a reviewWanjie Zhang0Shuwei Zhang1Xiaojie Li2Yan Qin Tan3Guangdong Provincial/ Zhuhai Key Laboratory of IRADS and Programme of Food Science and Technology, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, ChinaInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaCollege of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China; Corresponding authors.Guangdong Provincial/ Zhuhai Key Laboratory of IRADS and Programme of Food Science and Technology, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China; Corresponding authors.Cancer is among the leading causes of mortality across the globe. Despite the development of wide variety of oncotherapeutics, the effectiveness of oncotherapeutic drugs and anti-cancer bioactive compounds is frequently hindered by their low solubility and poor bioavailability, highlighting the need for efficient drug delivery system. Cyclodextrin (CD), a cyclic oligosaccharide produced by amylase hydrolysis of starch has emerged as promising candidates for drug delivery system due to their unique properties and low toxicity profile. This review comprehensively discussed the structure and properties of CD and its derivatives, as well as elucidated the synthesis and characterization of different types of CD-based drug delivery system including inclusion complex, nanoparticles, nanosponges, nanofibers, micelles, liposomes and hydrogels. The application of CD-based drug delivery system for oncotherapeutics was discussed and a forward-looking perspective on the challenges and prospects of CD-based drug delivery system demonstrated.http://www.sciencedirect.com/science/article/pii/S2666893925001525CyclodextrinOligosaccharidesDrug deliveryCancerOncotherapeutics |
| spellingShingle | Wanjie Zhang Shuwei Zhang Xiaojie Li Yan Qin Tan Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a review Carbohydrate Polymer Technologies and Applications Cyclodextrin Oligosaccharides Drug delivery Cancer Oncotherapeutics |
| title | Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a review |
| title_full | Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a review |
| title_fullStr | Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a review |
| title_full_unstemmed | Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a review |
| title_short | Synthesis, characterization and therapeutic advancements in cyclodextrin-based drug delivery systems for oncology: a review |
| title_sort | synthesis characterization and therapeutic advancements in cyclodextrin based drug delivery systems for oncology a review |
| topic | Cyclodextrin Oligosaccharides Drug delivery Cancer Oncotherapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925001525 |
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