On-site biosignal amplification using a single high-spin conjugated polymer
Abstract On-site or in-sensor biosignal transduction and amplification can offer several benefits such as improved signal quality, reduced redundant data transmission, and enhanced system integration. Ambipolar organic electrochemical transistors (OECTs) are promising for this purpose due to their h...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55369-6 |
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| author | Gao-Yang Ge Jingcao Xu Xinyue Wang Wenxi Sun Mo Yang Zi Mei Xin-Yu Deng Peiyun Li Xiran Pan Jia-Tong Li Xue-Qing Wang Zhi Zhang Shixian Lv Xiaochuan Dai Ting Lei |
| author_facet | Gao-Yang Ge Jingcao Xu Xinyue Wang Wenxi Sun Mo Yang Zi Mei Xin-Yu Deng Peiyun Li Xiran Pan Jia-Tong Li Xue-Qing Wang Zhi Zhang Shixian Lv Xiaochuan Dai Ting Lei |
| author_sort | Gao-Yang Ge |
| collection | DOAJ |
| description | Abstract On-site or in-sensor biosignal transduction and amplification can offer several benefits such as improved signal quality, reduced redundant data transmission, and enhanced system integration. Ambipolar organic electrochemical transistors (OECTs) are promising for this purpose due to their high transconductance, low operating voltage, biocompatibility, and suitability for miniaturized amplifier design. However, limitations in material performance and stability have hindered their application in biosignal amplification. Here, we propose using high-spin, hydrophilic conjugated polymers and a computational screening approach to address this challenge. We designed a high-spin polymer, namely P(TII-2FT), which exhibits satisfactory, stable, and balanced ambipolar OECT performance. The figure-of-merits achieved by the P(TII-2FT) devices surpass those of the current leading materials by 5 to 20 times, resulting in remarkable voltage gains while maintaining a compact form factor. Based on this amplifier, we have successfully achieved on-site capture and amplification of various electrophysiological signals with greatly enhanced signal quality. |
| format | Article |
| id | doaj-art-5d539678626e4724bdefbf01c0b4b58a |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-5d539678626e4724bdefbf01c0b4b58a2025-01-05T12:38:59ZengNature PortfolioNature Communications2041-17232025-01-0116111010.1038/s41467-024-55369-6On-site biosignal amplification using a single high-spin conjugated polymerGao-Yang Ge0Jingcao Xu1Xinyue Wang2Wenxi Sun3Mo Yang4Zi Mei5Xin-Yu Deng6Peiyun Li7Xiran Pan8Jia-Tong Li9Xue-Qing Wang10Zhi Zhang11Shixian Lv12Xiaochuan Dai13Ting Lei14National Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversitySchool of Biomedical Engineering, Tsinghua UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversitySchool of Biomedical Engineering, Tsinghua UniversitySchool and Hospital of Stomatology, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversitySchool of Biomedical Engineering, Tsinghua UniversityNational Key Laboratory of Advanced Micro and Nano Manufacture Technology, School of Materials Science and Engineering, Peking UniversityAbstract On-site or in-sensor biosignal transduction and amplification can offer several benefits such as improved signal quality, reduced redundant data transmission, and enhanced system integration. Ambipolar organic electrochemical transistors (OECTs) are promising for this purpose due to their high transconductance, low operating voltage, biocompatibility, and suitability for miniaturized amplifier design. However, limitations in material performance and stability have hindered their application in biosignal amplification. Here, we propose using high-spin, hydrophilic conjugated polymers and a computational screening approach to address this challenge. We designed a high-spin polymer, namely P(TII-2FT), which exhibits satisfactory, stable, and balanced ambipolar OECT performance. The figure-of-merits achieved by the P(TII-2FT) devices surpass those of the current leading materials by 5 to 20 times, resulting in remarkable voltage gains while maintaining a compact form factor. Based on this amplifier, we have successfully achieved on-site capture and amplification of various electrophysiological signals with greatly enhanced signal quality.https://doi.org/10.1038/s41467-024-55369-6 |
| spellingShingle | Gao-Yang Ge Jingcao Xu Xinyue Wang Wenxi Sun Mo Yang Zi Mei Xin-Yu Deng Peiyun Li Xiran Pan Jia-Tong Li Xue-Qing Wang Zhi Zhang Shixian Lv Xiaochuan Dai Ting Lei On-site biosignal amplification using a single high-spin conjugated polymer Nature Communications |
| title | On-site biosignal amplification using a single high-spin conjugated polymer |
| title_full | On-site biosignal amplification using a single high-spin conjugated polymer |
| title_fullStr | On-site biosignal amplification using a single high-spin conjugated polymer |
| title_full_unstemmed | On-site biosignal amplification using a single high-spin conjugated polymer |
| title_short | On-site biosignal amplification using a single high-spin conjugated polymer |
| title_sort | on site biosignal amplification using a single high spin conjugated polymer |
| url | https://doi.org/10.1038/s41467-024-55369-6 |
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