Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure
<b>Background/Objectives:</b> This study investigated the lifetime attributable risk (LAR) of radiation-induced breast cancer from mammography screening in Dubai. It aimed to explore the relationship between breast thickness, patient age, and the associated radiation dose during mammogra...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/1/83 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841549270096805888 |
|---|---|
| author | Kaltham Abdulwahid Mohd Noor Norhashimah Mohd Norsuddin Iza Nurzawani Che Isa Muhammad Khalis Abdul Karim |
| author_facet | Kaltham Abdulwahid Mohd Noor Norhashimah Mohd Norsuddin Iza Nurzawani Che Isa Muhammad Khalis Abdul Karim |
| author_sort | Kaltham Abdulwahid Mohd Noor |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> This study investigated the lifetime attributable risk (LAR) of radiation-induced breast cancer from mammography screening in Dubai. It aimed to explore the relationship between breast thickness, patient age, and the associated radiation dose during mammographic examinations. <b>Methods:</b> A retrospective analysis was conducted on 2601 patients aged 40 to 69 across five screening facilities in Dubai’s healthcare system. Due to a low correlation between the mean glandular dose (MGD) and breast thickness, both glandular and non-glandular doses were included in calculations as the organ dose (OD). This comprehensive approach examined the impact of whole breast tissue on risk assessments. Key exposure parameters such as the kilovoltage peak (kVp), milliampere-seconds (mAs), and source-to-skin distance were extracted from the dose survey. <b>Results:</b> Our findings reveal that the organ dose increases with breast thickness, emphasizing the need for dose optimization in denser tissues. The LAR decreases with age across all thickness categories, but higher initial LAR values were seen in younger patients with thicker tissue. This study emphasizes the increased sensitivity of younger women, who usually have denser breast tissue, to radiation-induced cancer risks. <b>Conclusions:</b> Personalized screening protocols considering age and breast thickness are crucial for balancing early cancer detection benefits with radiation risks. Future research should improve mammography protocols, explore alternative methods, and consider generic testing for young high-risk patients to mitigate risks while maintaining diagnostic efficacy. |
| format | Article |
| id | doaj-art-5d52b33685614c9088c8a42c0d10c59f |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-5d52b33685614c9088c8a42c0d10c59f2025-01-10T13:16:40ZengMDPI AGDiagnostics2075-44182025-01-011518310.3390/diagnostics15010083Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation ExposureKaltham Abdulwahid Mohd Noor0Norhashimah Mohd Norsuddin1Iza Nurzawani Che Isa2Muhammad Khalis Abdul Karim3Centre of Diagnostic, Therapeutic and Investigative Studies (CODTIS), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaCentre of Diagnostic, Therapeutic and Investigative Studies (CODTIS), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaCentre of Diagnostic, Therapeutic and Investigative Studies (CODTIS), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaDepartment of Physics, Faculty of Science, University Putra Malaysia, Serdang 43400, Malaysia<b>Background/Objectives:</b> This study investigated the lifetime attributable risk (LAR) of radiation-induced breast cancer from mammography screening in Dubai. It aimed to explore the relationship between breast thickness, patient age, and the associated radiation dose during mammographic examinations. <b>Methods:</b> A retrospective analysis was conducted on 2601 patients aged 40 to 69 across five screening facilities in Dubai’s healthcare system. Due to a low correlation between the mean glandular dose (MGD) and breast thickness, both glandular and non-glandular doses were included in calculations as the organ dose (OD). This comprehensive approach examined the impact of whole breast tissue on risk assessments. Key exposure parameters such as the kilovoltage peak (kVp), milliampere-seconds (mAs), and source-to-skin distance were extracted from the dose survey. <b>Results:</b> Our findings reveal that the organ dose increases with breast thickness, emphasizing the need for dose optimization in denser tissues. The LAR decreases with age across all thickness categories, but higher initial LAR values were seen in younger patients with thicker tissue. This study emphasizes the increased sensitivity of younger women, who usually have denser breast tissue, to radiation-induced cancer risks. <b>Conclusions:</b> Personalized screening protocols considering age and breast thickness are crucial for balancing early cancer detection benefits with radiation risks. Future research should improve mammography protocols, explore alternative methods, and consider generic testing for young high-risk patients to mitigate risks while maintaining diagnostic efficacy.https://www.mdpi.com/2075-4418/15/1/83life attribute risk (LAR)mean glandular dose (MGD)organ dose (OD)breast-screening mammographyradiation dose optimizationpatient-specific mammography protocols |
| spellingShingle | Kaltham Abdulwahid Mohd Noor Norhashimah Mohd Norsuddin Iza Nurzawani Che Isa Muhammad Khalis Abdul Karim Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure Diagnostics life attribute risk (LAR) mean glandular dose (MGD) organ dose (OD) breast-screening mammography radiation dose optimization patient-specific mammography protocols |
| title | Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure |
| title_full | Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure |
| title_fullStr | Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure |
| title_full_unstemmed | Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure |
| title_short | Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure |
| title_sort | lifetime attributable risk in mammography screenings in dubai the influence of breast thickness and age on radiation exposure |
| topic | life attribute risk (LAR) mean glandular dose (MGD) organ dose (OD) breast-screening mammography radiation dose optimization patient-specific mammography protocols |
| url | https://www.mdpi.com/2075-4418/15/1/83 |
| work_keys_str_mv | AT kalthamabdulwahidmohdnoor lifetimeattributableriskinmammographyscreeningsindubaitheinfluenceofbreastthicknessandageonradiationexposure AT norhashimahmohdnorsuddin lifetimeattributableriskinmammographyscreeningsindubaitheinfluenceofbreastthicknessandageonradiationexposure AT izanurzawanicheisa lifetimeattributableriskinmammographyscreeningsindubaitheinfluenceofbreastthicknessandageonradiationexposure AT muhammadkhalisabdulkarim lifetimeattributableriskinmammographyscreeningsindubaitheinfluenceofbreastthicknessandageonradiationexposure |