Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

IntroductionTissue repair can be promoted by moderate inflammation but suppressed by excessive levels. Therefore, control of excessive inflammation following removal of infection plays a critical role in promotion of pulpal repair. Connexin 43 (Cx43) forms hemichannels (HCs) or gap channels (GJs) to...

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Bibliographic Details
Main Authors: Peiling Hu, Ping Long, Ruotong Li, Xiaorong Lan, Yuanpei He, Guangwen Li, Shiting Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Oral Health
Subjects:
deep caries
connexin43 hemichannel
inflammatory response
dental pulp cells
DAMPs
Online Access:https://www.frontiersin.org/articles/10.3389/froh.2024.1496819/full
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