Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia
<b>Aim:</b> The purpose of the study was to determine the levels of acute phase proteins and clinical changes in calves with lipopolysaccharide induced experimental endotoxemia.<p> <b>Materials and Methods:</b> Eight Holstein breed calves were used in the study. Endotox...
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=460 |
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| author | Alparslan Coskun lsmail Sen |
| author_facet | Alparslan Coskun lsmail Sen |
| author_sort | Alparslan Coskun |
| collection | DOAJ |
| description | <b>Aim:</b> The purpose of the study was to determine the levels
of acute phase proteins and clinical changes in calves with
lipopolysaccharide induced experimental endotoxemia.<p>
<b>Materials and Methods:</b> Eight Holstein breed calves were
used in the study. Endotoxemia was induced via intravenous
administration of 0.1 μg/kg dose of lipopolysaccharide in
50 mL of physiological 0.9% NaCl over 30 min. The calves
were continuously observed for clinical changes during the
experiment, and serum acute phase protein levels were
measured.<p>
<b>Results:</b> Increase in respiratory frequency, tachycardi,
mucosal hyperemia/cyanosis, recumbency, depression,
hyperthermia/hypothermia, and poor suckle reflexes were
observed in all calves after lipopolysaccharide administration.
After lipopolysaccharide infusion, serum haptoglobin
(500±93.2 μg/mL) and serum amyloid A (185±46.6) concentrations
reached peak levels of at 36 h and 24 h, respectively.<p>
<b>Conclusion:</b> Changes in acute phase proteins and clinical
findings were related to endotoxemia. A moderate to high
increase in haptoglobin and serum amyloid A concentrations
may indicate the presence of endotoxemia in calves. |
| format | Article |
| id | doaj-art-5d334c4b5ec74a8bb7124a258970dbbc |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-5d334c4b5ec74a8bb7124a258970dbbc2025-01-03T01:36:14ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532812126460Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemiaAlparslan Coskun0lsmail Sen1Department of Internal Medicine, Faculty of Veterinary, Medicine, Cumhuriyet University, SivasDepartment of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey<b>Aim:</b> The purpose of the study was to determine the levels of acute phase proteins and clinical changes in calves with lipopolysaccharide induced experimental endotoxemia.<p> <b>Materials and Methods:</b> Eight Holstein breed calves were used in the study. Endotoxemia was induced via intravenous administration of 0.1 μg/kg dose of lipopolysaccharide in 50 mL of physiological 0.9% NaCl over 30 min. The calves were continuously observed for clinical changes during the experiment, and serum acute phase protein levels were measured.<p> <b>Results:</b> Increase in respiratory frequency, tachycardi, mucosal hyperemia/cyanosis, recumbency, depression, hyperthermia/hypothermia, and poor suckle reflexes were observed in all calves after lipopolysaccharide administration. After lipopolysaccharide infusion, serum haptoglobin (500±93.2 μg/mL) and serum amyloid A (185±46.6) concentrations reached peak levels of at 36 h and 24 h, respectively.<p> <b>Conclusion:</b> Changes in acute phase proteins and clinical findings were related to endotoxemia. A moderate to high increase in haptoglobin and serum amyloid A concentrations may indicate the presence of endotoxemia in calves.http://eurasianjvetsci.org/pdf.php3?id=460acute phase proteinsendotoxemiacalvesclinical score |
| spellingShingle | Alparslan Coskun lsmail Sen Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia Eurasian Journal of Veterinary Sciences acute phase proteins endotoxemia calves clinical score |
| title | Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia |
| title_full | Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia |
| title_fullStr | Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia |
| title_full_unstemmed | Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia |
| title_short | Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia |
| title_sort | acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia |
| topic | acute phase proteins endotoxemia calves clinical score |
| url | http://eurasianjvetsci.org/pdf.php3?id=460 |
| work_keys_str_mv | AT alparslancoskun acutephaseresponseandclinicalchangesincalveswithlipopolysaccharideinducedendotoxemia AT lsmailsen acutephaseresponseandclinicalchangesincalveswithlipopolysaccharideinducedendotoxemia |