Ligand-to-Metal Ratio Governs Radical-Scavenging Ability of Malate-Stabilised Ceria Nanoparticles
Cerium dioxide sols stabilised with L-malic acid were shown to exhibit significant antioxidant activity towards alkyl peroxyl radicals in the range of ligand:CeO<sub>2</sub> molar ratios of 0.2–1 (0.2:1, 0.4:1, 0.5:1, 0.6:1, 0.8:1 and 1:1). The antioxidant activity of cerium dioxide nano...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/14/23/1908 |
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| Summary: | Cerium dioxide sols stabilised with L-malic acid were shown to exhibit significant antioxidant activity towards alkyl peroxyl radicals in the range of ligand:CeO<sub>2</sub> molar ratios of 0.2–1 (0.2:1, 0.4:1, 0.5:1, 0.6:1, 0.8:1 and 1:1). The antioxidant activity of cerium dioxide nanoparticles greatly depended on L-malic acid content and increased by 8 times when the ligand:CeO<sub>2</sub> molar ratio increased from 0.2:1 to 0.4:1. An estimate of the ligand:CeO<sub>2</sub> molar ratio required to ensure complete surface coverage of CeO<sub>2</sub> nanoparticles with malate anions resulted in a value of 0.2. Aggregation degree of CeO<sub>2</sub> nanoparticles depends on the ligand:CeO<sub>2</sub> molar ratio. In the range of ligand:CeO<sub>2</sub> molar ratios 0.2–0.4, the size of aggregates decreased by an order of magnitude. The antioxidant capacity of 1 mM malate-stabilised cerium dioxide (0.2:1) relative to sodium ascorbate was 0.012 ± 0.001 mM. The antioxidant activity of cerium dioxide stabilised with L-malic acid at a ligand:CeO<sub>2</sub> molar ratio of 0.2:1 was 80 times less than the antioxidant activity of sodium ascorbate. Cerium dioxide nanoparticles stabilised with L-malic acid did not demonstrate a cytotoxic effect against human mesenchymal stem cells, in a wide range of concentrations (10<sup>−3</sup>–10<sup>−5</sup> M), and their proliferation was stimulated after 72 h of cultivation. The results obtained show new possibilities for the design of biocompatible ceria-based nanomaterials with tunable pro- and antioxidant properties; these materials can further be assessed in view of their potential for treating oxidative stress-related disorders. |
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| ISSN: | 2079-4991 |