A FACILE SYNTHESIS OF (S) – (-) – PROPRANOLOL
A one-pot synthesis of (S)-(-)-propranolol is reported. Zn(NO3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (S)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield.
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| Format: | Article |
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| Language: | English |
| Published: |
University of Tehran
2003-03-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31698_fc043ad01abf1ff8853689fea8048fff.pdf |
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| Summary: | A one-pot synthesis of (S)-(-)-propranolol is reported. Zn(NO3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (S)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield. |
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| ISSN: | 1016-1104 2345-6914 |