Non-contrast enhanced functional lung MRI in children: systematic review
ObjectivesMagnetic resonance imaging (MRI) of the lung is well suited for repeated measurements especially in children due to the absence of ionizing radiation. Furthermore, non-contrast-enhanced (NCE) functional MRI techniques provide localized functional information on ventilation and perfusion wi...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1568172/full |
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| author | Carmen Streibel Carmen Streibel Carmen Streibel Grzegorz Bauman Grzegorz Bauman Oliver Bieri Oliver Bieri Orso Pusterla Orso Pusterla Orso Pusterla Enno Stranzinger Marion Curdy Philipp Latzin Elisabeth Kieninger |
| author_facet | Carmen Streibel Carmen Streibel Carmen Streibel Grzegorz Bauman Grzegorz Bauman Oliver Bieri Oliver Bieri Orso Pusterla Orso Pusterla Orso Pusterla Enno Stranzinger Marion Curdy Philipp Latzin Elisabeth Kieninger |
| author_sort | Carmen Streibel |
| collection | DOAJ |
| description | ObjectivesMagnetic resonance imaging (MRI) of the lung is well suited for repeated measurements especially in children due to the absence of ionizing radiation. Furthermore, non-contrast-enhanced (NCE) functional MRI techniques provide localized functional information on ventilation and perfusion without specialized set-ups (e.g., hyperpolarized gases) using standard clinical MRI systems. Current NCE-MRI techniques in the pediatric setting are matrix-pencil decomposition (MP)-MRI, phase-resolved functional lung (PREFUL)-MRI, self-gated non-contrast-enhanced functional lung (SENCEFUL)-MRI and Fourier decomposition (FD)-MRI. In this article, we comprehensively discuss these innovative techniques.Study designWe review relevant functional NCE-MRI techniques based on a systematic literature research in MEDLINE, Embase, Cochrane Library, ClinicalTrials.gov and ICTRP. Core concepts were: 1. Aspects regarding lungs 2. MP-, PREFUL-, SENCEFUL and FD-MRI, and 3. children. Consecutively, we included 30 reports.ResultsFunctional NCE-MRI in the pediatric setting has been successfully validated and used in observational studies covering a great variety of lung diseases. In contrast to initial implementation studies additionally reporting on clinical findings, later studies focus primarily on clinical topics. Heterogeneous study designs and examination protocols hamper the direct comparability between the different NCE-MRI techniques in terms of their performance against current functional imaging standards or specific objectives.ConclusionTheir easy applicability makes NCE-MRI techniques highly attractive for widespread clinical use. Following successful implementation studies, still varying test protocols and approaches for calculating outcome values must next be compared and standardized. |
| format | Article |
| id | doaj-art-5d1911c7c19148f4b8d62b23e7a1aa7d |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-5d1911c7c19148f4b8d62b23e7a1aa7d2025-08-20T03:55:53ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-07-011310.3389/fped.2025.15681721568172Non-contrast enhanced functional lung MRI in children: systematic reviewCarmen Streibel0Carmen Streibel1Carmen Streibel2Grzegorz Bauman3Grzegorz Bauman4Oliver Bieri5Oliver Bieri6Orso Pusterla7Orso Pusterla8Orso Pusterla9Enno Stranzinger10Marion Curdy11Philipp Latzin12Elisabeth Kieninger13Department of Paediatrics, Division of Paediatric Respiratory Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandGraduate School for Health Sciences, University of Bern, Bern, SwitzerlandDepartment of General Internal Medicine and Psychosomatic, Heidelberg University Hospital, University of Heidelberg, Heidelberg, GermanyDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Allschwil, SwitzerlandDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Allschwil, SwitzerlandDepartment of Paediatrics, Division of Paediatric Respiratory Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Allschwil, SwitzerlandDepartment of Diagnostic and Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, Bern, SwitzerlandDepartment of Paediatrics, Division of Paediatric Respiratory Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Paediatrics, Division of Paediatric Respiratory Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Paediatrics, Division of Paediatric Respiratory Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandObjectivesMagnetic resonance imaging (MRI) of the lung is well suited for repeated measurements especially in children due to the absence of ionizing radiation. Furthermore, non-contrast-enhanced (NCE) functional MRI techniques provide localized functional information on ventilation and perfusion without specialized set-ups (e.g., hyperpolarized gases) using standard clinical MRI systems. Current NCE-MRI techniques in the pediatric setting are matrix-pencil decomposition (MP)-MRI, phase-resolved functional lung (PREFUL)-MRI, self-gated non-contrast-enhanced functional lung (SENCEFUL)-MRI and Fourier decomposition (FD)-MRI. In this article, we comprehensively discuss these innovative techniques.Study designWe review relevant functional NCE-MRI techniques based on a systematic literature research in MEDLINE, Embase, Cochrane Library, ClinicalTrials.gov and ICTRP. Core concepts were: 1. Aspects regarding lungs 2. MP-, PREFUL-, SENCEFUL and FD-MRI, and 3. children. Consecutively, we included 30 reports.ResultsFunctional NCE-MRI in the pediatric setting has been successfully validated and used in observational studies covering a great variety of lung diseases. In contrast to initial implementation studies additionally reporting on clinical findings, later studies focus primarily on clinical topics. Heterogeneous study designs and examination protocols hamper the direct comparability between the different NCE-MRI techniques in terms of their performance against current functional imaging standards or specific objectives.ConclusionTheir easy applicability makes NCE-MRI techniques highly attractive for widespread clinical use. Following successful implementation studies, still varying test protocols and approaches for calculating outcome values must next be compared and standardized.https://www.frontiersin.org/articles/10.3389/fped.2025.1568172/fullfunctional lung MRIchildrenlung functionMP-MRIpulmonologylung imaging |
| spellingShingle | Carmen Streibel Carmen Streibel Carmen Streibel Grzegorz Bauman Grzegorz Bauman Oliver Bieri Oliver Bieri Orso Pusterla Orso Pusterla Orso Pusterla Enno Stranzinger Marion Curdy Philipp Latzin Elisabeth Kieninger Non-contrast enhanced functional lung MRI in children: systematic review Frontiers in Pediatrics functional lung MRI children lung function MP-MRI pulmonology lung imaging |
| title | Non-contrast enhanced functional lung MRI in children: systematic review |
| title_full | Non-contrast enhanced functional lung MRI in children: systematic review |
| title_fullStr | Non-contrast enhanced functional lung MRI in children: systematic review |
| title_full_unstemmed | Non-contrast enhanced functional lung MRI in children: systematic review |
| title_short | Non-contrast enhanced functional lung MRI in children: systematic review |
| title_sort | non contrast enhanced functional lung mri in children systematic review |
| topic | functional lung MRI children lung function MP-MRI pulmonology lung imaging |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1568172/full |
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