Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

Abstract The immunologic consequences of using bactericidal versus bacteriostatic antibiotic treatments are unclear. We observed a bacteriostatic (growth halting) treatment was more protective than a bactericidal (bacteria killing) treatment in a murine peritonitis model. To understand this unexpect...

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Bibliographic Details
Main Authors: Julia L. Gross, Rahul Basu, Clinton J. Bradfield, Jing Sun, Sinu P. John, Sanchita Das, John P. Dekker, David S. Weiss, Iain D. C. Fraser
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54497-3
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