Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system
Abstract Background There is a need for faster amyloid PET scans to reduce patients’ discomfort, minimize movement artifacts, and increase throughput. The recently introduced uMI Panorama PET/CT system featuring enhanced spatial resolution and sub-200ps TOF offers the potential for shorter scan dura...
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SpringerOpen
2024-12-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-024-00712-5 |
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| author | Xueqian Yang Meiqi Wu Menglin Liang Haiqiong Zhang Bo Li Chenhui Mao Liling Dong Yuan Wang Haiqun Xing Chao Ren Zhenghai Huang Qingxiang Wen Qi Ge Zhengqing Yu Feng Feng Jing Gao Li Huo |
| author_facet | Xueqian Yang Meiqi Wu Menglin Liang Haiqiong Zhang Bo Li Chenhui Mao Liling Dong Yuan Wang Haiqun Xing Chao Ren Zhenghai Huang Qingxiang Wen Qi Ge Zhengqing Yu Feng Feng Jing Gao Li Huo |
| author_sort | Xueqian Yang |
| collection | DOAJ |
| description | Abstract Background There is a need for faster amyloid PET scans to reduce patients’ discomfort, minimize movement artifacts, and increase throughput. The recently introduced uMI Panorama PET/CT system featuring enhanced spatial resolution and sub-200ps TOF offers the potential for shorter scan duration without sacrificing image quality or efficacy to detect Aβ deposition. The study aims to establish a faster acquisition protocol for [18F]florbetapir PET imaging using digital PET/CT scanner uMI Panorama, while ensuring adequate image quality and amyloid-β (Aβ) detectability comparable to the standard 10-minute scan. Methods Thirty-eight participants (29 Aβ positive and 9 Aβ negative) from a prospective dementia cohort at Peking Union Medical University Hospital underwent routine [18F]florbetapir PET scans using the uMI Panorama PET/CT scanner and a T1-weighted brain MRI scan. List-mode PET data were reconstructed into durations of 10 min, 2 min, 1 min, 45 s, and 30 s (G10min, G2min, G1min, G45s, G30s). Two trained nuclear medicine physicians independently evaluated the image quality using a 5-point scale and provided binary diagnosis. Standardized uptake value ratios (SUVr) of the composite cortex (frontal, lateral parietal, lateral temporal, and cingulate cortices) were calculated to discriminate Aβ status and coefficient of variation assessed objective image quality. Comparisons of image quality and Aβ detectability between various fast scan groups and G10min group were conducted. Results The subjective image quality evaluation and Aβ detectability results from the two physicians showed both good intra-reader and inter-reader agreements (Cohen’s kappa coefficient: 0.759-1.000). The subjective and objective image qualities of the G2min scans were comparable to the G10min scans, whereas adequate image quality was achieved with the G1min and G45s scans (5-point score ≥ 3). Subjective visual diagnosis by two physicians yielded consistent accuracy for G10min, G2min, and G1min groups, but lower specificity for G45s and G30s groups. The objective detection of Aβ status by cortex SUVr across all scan durations maintained perfect discriminatory efficiency and relatively high effect size (Hedge’s G: 2.48–2.54). Conclusions A 1-min ultra-fast scan is feasible for [18F]florbetapir PET imaging using uMI Panorama PET/CT, while maintaining adequate image quality and Aβ diagnostic efficiency. Clinical trial registration NCT05023564. Registered September 2022 https://clinicaltrials.gov/search?term=NCT05023564 . |
| format | Article |
| id | doaj-art-5cedc402fed247cd8ad70dc0085ff246 |
| institution | Kabale University |
| issn | 2197-7364 |
| language | English |
| publishDate | 2024-12-01 |
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| series | EJNMMI Physics |
| spelling | doaj-art-5cedc402fed247cd8ad70dc0085ff2462025-01-05T12:46:38ZengSpringerOpenEJNMMI Physics2197-73642024-12-0111111210.1186/s40658-024-00712-5Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT systemXueqian Yang0Meiqi Wu1Menglin Liang2Haiqiong Zhang3Bo Li4Chenhui Mao5Liling Dong6Yuan Wang7Haiqun Xing8Chao Ren9Zhenghai Huang10Qingxiang Wen11Qi Ge12Zhengqing Yu13Feng Feng14Jing Gao15Li Huo16Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Neurology, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Neurology, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Neurology, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing Hospital of Traditional Chinese Medicine, Capital Medical UniversityCentral Research Institute, United Imaging HealthcareCentral Research Institute, United Imaging HealthcareDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Neurology, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeAbstract Background There is a need for faster amyloid PET scans to reduce patients’ discomfort, minimize movement artifacts, and increase throughput. The recently introduced uMI Panorama PET/CT system featuring enhanced spatial resolution and sub-200ps TOF offers the potential for shorter scan duration without sacrificing image quality or efficacy to detect Aβ deposition. The study aims to establish a faster acquisition protocol for [18F]florbetapir PET imaging using digital PET/CT scanner uMI Panorama, while ensuring adequate image quality and amyloid-β (Aβ) detectability comparable to the standard 10-minute scan. Methods Thirty-eight participants (29 Aβ positive and 9 Aβ negative) from a prospective dementia cohort at Peking Union Medical University Hospital underwent routine [18F]florbetapir PET scans using the uMI Panorama PET/CT scanner and a T1-weighted brain MRI scan. List-mode PET data were reconstructed into durations of 10 min, 2 min, 1 min, 45 s, and 30 s (G10min, G2min, G1min, G45s, G30s). Two trained nuclear medicine physicians independently evaluated the image quality using a 5-point scale and provided binary diagnosis. Standardized uptake value ratios (SUVr) of the composite cortex (frontal, lateral parietal, lateral temporal, and cingulate cortices) were calculated to discriminate Aβ status and coefficient of variation assessed objective image quality. Comparisons of image quality and Aβ detectability between various fast scan groups and G10min group were conducted. Results The subjective image quality evaluation and Aβ detectability results from the two physicians showed both good intra-reader and inter-reader agreements (Cohen’s kappa coefficient: 0.759-1.000). The subjective and objective image qualities of the G2min scans were comparable to the G10min scans, whereas adequate image quality was achieved with the G1min and G45s scans (5-point score ≥ 3). Subjective visual diagnosis by two physicians yielded consistent accuracy for G10min, G2min, and G1min groups, but lower specificity for G45s and G30s groups. The objective detection of Aβ status by cortex SUVr across all scan durations maintained perfect discriminatory efficiency and relatively high effect size (Hedge’s G: 2.48–2.54). Conclusions A 1-min ultra-fast scan is feasible for [18F]florbetapir PET imaging using uMI Panorama PET/CT, while maintaining adequate image quality and Aβ diagnostic efficiency. Clinical trial registration NCT05023564. Registered September 2022 https://clinicaltrials.gov/search?term=NCT05023564 .https://doi.org/10.1186/s40658-024-00712-5Ultra-fast PET scanβ-AmyloidDigital PET/CT[18F]florbetapirImage quality |
| spellingShingle | Xueqian Yang Meiqi Wu Menglin Liang Haiqiong Zhang Bo Li Chenhui Mao Liling Dong Yuan Wang Haiqun Xing Chao Ren Zhenghai Huang Qingxiang Wen Qi Ge Zhengqing Yu Feng Feng Jing Gao Li Huo Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system EJNMMI Physics Ultra-fast PET scan β-Amyloid Digital PET/CT [18F]florbetapir Image quality |
| title | Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system |
| title_full | Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system |
| title_fullStr | Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system |
| title_full_unstemmed | Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system |
| title_short | Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system |
| title_sort | ultra fast 18f florbetapir pet imaging using the umi panorama pet ct system |
| topic | Ultra-fast PET scan β-Amyloid Digital PET/CT [18F]florbetapir Image quality |
| url | https://doi.org/10.1186/s40658-024-00712-5 |
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