Enrichment of gut-derived metabolites in a Parkinson’s disease subtype with REM sleep behavior disorder

Abstract Recent reports indicate that Parkinson’s disease (PD)-like changes in gut microbial signatures develop in idiopathic REM sleep behavior disorder (iRBD), a prodrome of α-synucleinopathies. However, <50% of PD cases exhibit RBD at onset, underscoring PD’s heterogeneity. Using untargeted me...

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Bibliographic Details
Main Authors: Sunjae Lee, Jihyun Kim, Jae Woo Baek, Ki-Young Jung, Yunjong Lee, Ara Koh, Han-Joon Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01040-w
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