A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing
Abstract Gastric pain has limited treatment options and the mechanisms within the central circuitry remain largely unclear. This study investigates the central circuitry in gastric pain induced by noxious gastric distension (GD) in mice. Here, we identified that the nucleus tractus solitarius (NTS)...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54056-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846165117798973440 |
|---|---|
| author | Fu-Chao Zhang Rui-Xia Weng Di Li Yong-Chang Li Xiao-Xuan Dai Shufen Hu Qian Sun Rui Li Guang-Yin Xu |
| author_facet | Fu-Chao Zhang Rui-Xia Weng Di Li Yong-Chang Li Xiao-Xuan Dai Shufen Hu Qian Sun Rui Li Guang-Yin Xu |
| author_sort | Fu-Chao Zhang |
| collection | DOAJ |
| description | Abstract Gastric pain has limited treatment options and the mechanisms within the central circuitry remain largely unclear. This study investigates the central circuitry in gastric pain induced by noxious gastric distension (GD) in mice. Here, we identified that the nucleus tractus solitarius (NTS) serves as the first-level center of gastric pain, primarily via the vagus nerve. The prelimbic cortex (PL) is engaged in the perception of gastric pain. The lateral parabrachial nucleus (LPB) and the paraventricular thalamic nucleus (PVT) are crucial regions for synaptic transmission from the NTS to the PL. The glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuitry is necessary and sufficient for the processing of gastric pain. Overall, our finding reveals a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuitry that transmits gastric nociceptive signaling by the vagus nerve in mice. It provides an insight into the gastric pain ascending pathway and offers potential therapeutic targets for relieving visceral pain. |
| format | Article |
| id | doaj-art-5cbf59ec2f884937b4f1f3a0d6d8b694 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-5cbf59ec2f884937b4f1f3a0d6d8b6942024-11-17T12:35:48ZengNature PortfolioNature Communications2041-17232024-11-0115111610.1038/s41467-024-54056-wA vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processingFu-Chao Zhang0Rui-Xia Weng1Di Li2Yong-Chang Li3Xiao-Xuan Dai4Shufen Hu5Qian Sun6Rui Li7Guang-Yin Xu8Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow UniversityClinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow UniversityClinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow UniversityClinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow UniversityClinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow UniversityClinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Soochow UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Soochow UniversityClinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow UniversityAbstract Gastric pain has limited treatment options and the mechanisms within the central circuitry remain largely unclear. This study investigates the central circuitry in gastric pain induced by noxious gastric distension (GD) in mice. Here, we identified that the nucleus tractus solitarius (NTS) serves as the first-level center of gastric pain, primarily via the vagus nerve. The prelimbic cortex (PL) is engaged in the perception of gastric pain. The lateral parabrachial nucleus (LPB) and the paraventricular thalamic nucleus (PVT) are crucial regions for synaptic transmission from the NTS to the PL. The glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuitry is necessary and sufficient for the processing of gastric pain. Overall, our finding reveals a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuitry that transmits gastric nociceptive signaling by the vagus nerve in mice. It provides an insight into the gastric pain ascending pathway and offers potential therapeutic targets for relieving visceral pain.https://doi.org/10.1038/s41467-024-54056-w |
| spellingShingle | Fu-Chao Zhang Rui-Xia Weng Di Li Yong-Chang Li Xiao-Xuan Dai Shufen Hu Qian Sun Rui Li Guang-Yin Xu A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing Nature Communications |
| title | A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing |
| title_full | A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing |
| title_fullStr | A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing |
| title_full_unstemmed | A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing |
| title_short | A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing |
| title_sort | vagus nerve dominant tetra synaptic ascending pathway for gastric pain processing |
| url | https://doi.org/10.1038/s41467-024-54056-w |
| work_keys_str_mv | AT fuchaozhang avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT ruixiaweng avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT dili avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT yongchangli avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT xiaoxuandai avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT shufenhu avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT qiansun avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT ruili avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT guangyinxu avagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT fuchaozhang vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT ruixiaweng vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT dili vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT yongchangli vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT xiaoxuandai vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT shufenhu vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT qiansun vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT ruili vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing AT guangyinxu vagusnervedominanttetrasynapticascendingpathwayforgastricpainprocessing |