Characterization of Epithelial–Mesenchymal and Neuroendocrine Differentiation States in Pancreatic and Small Cell Ovarian Tumor Cells and Their Modulation by TGF-β1 and BMP-7

Characterization of Epithelial–Mesenchymal and Neuroendocrine Differentiation States in Pancreatic and Small Cell Ovarian Tumor Cells and Their Modulation by TGF-β1 and BMP-7

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, due in part to early invasion and metastasis, which in turn involves epithelial–mesenchymal transition (EMT) of the cancer cells. Prompted by the discovery that two PDAC cell lines of the quasi-mesenchymal subtype (PANC-1, MIA...

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Main Authors: Hendrik Ungefroren, Juliane von der Ohe, Rüdiger Braun, Yola Gätje, Olha Lapshyna, Jörg Schrader, Hendrik Lehnert, Jens-Uwe Marquardt, Björn Konukiewitz, Ralf Hass
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
pancreatic ductal adenocarcinoma
epithelial–mesenchymal transition
mesenchymal–epithelial transition
neuroendocrine differentiation
TGF-β
Online Access:https://www.mdpi.com/2073-4409/13/23/2010
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https://www.mdpi.com/2073-4409/13/23/2010

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