Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in children
Abstract Introduction Despite the growing evidence on efficacy, little is known regarding the efficiency of Vitamin D supplementation (VDS) to reduce the incidence of repeat episodes of pneumonia in children. This study aimed to determine the cost-utility of VDS to reduce the incidence rate of repea...
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BMC
2024-11-01
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| Series: | Cost Effectiveness and Resource Allocation |
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| Online Access: | https://doi.org/10.1186/s12962-024-00589-2 |
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| author | Jefferson Antonio Buendía Diana Guerrero Patiño |
| author_facet | Jefferson Antonio Buendía Diana Guerrero Patiño |
| author_sort | Jefferson Antonio Buendía |
| collection | DOAJ |
| description | Abstract Introduction Despite the growing evidence on efficacy, little is known regarding the efficiency of Vitamin D supplementation (VDS) to reduce the incidence of repeat episodes of pneumonia in children. This study aimed to determine the cost-utility of VDS to reduce the incidence rate of repeat episodes of pneumonia in children. Methods A decision tree model was used to estimate the cost and quality-adjusted life-years (QALYs) of VDS in a patient aged 2 to 60 months with a clinical diagnosis of community-acquired pneumonia requiring in-hospital management. Multiple sensitivity analyses were conducted to evaluate the robustness of the model. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180. Results The QALYs per person were 0,93 with VDS and 0,92 without VDS. The total costs per person were US$ 1148 for VDS and US$ 1284 without VDS. This position of absolute dominance of VDS makes it unnecessary to estimate the incremental cost-effectiveness ratio. The ICER was sensitive to changes in the relative risk of Vitamin D supplementation. Conclusion In conclusion, our study shows that VDS is a cost-effective to reduce the incidence rate of repeat episodes of pneumonia in children, from a societal perspective. However, the sensitivity of ICER to relative risk makes it necessary to take the results of this economic evaluation with caution. |
| format | Article |
| id | doaj-art-5c5ba3fdc64e4b8bbeb6f8b19e166128 |
| institution | Kabale University |
| issn | 1478-7547 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cost Effectiveness and Resource Allocation |
| spelling | doaj-art-5c5ba3fdc64e4b8bbeb6f8b19e1661282024-11-17T12:30:46ZengBMCCost Effectiveness and Resource Allocation1478-75472024-11-012211710.1186/s12962-024-00589-2Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in childrenJefferson Antonio Buendía0Diana Guerrero Patiño1Research group in Pharmacology and Toxicology ”INFARTO”, Department of Pharmacology and Toxicology, University of AntioquiaResearch group in Pharmacology and Toxicology ”INFARTO”, Department of Pharmacology and Toxicology, University of AntioquiaAbstract Introduction Despite the growing evidence on efficacy, little is known regarding the efficiency of Vitamin D supplementation (VDS) to reduce the incidence of repeat episodes of pneumonia in children. This study aimed to determine the cost-utility of VDS to reduce the incidence rate of repeat episodes of pneumonia in children. Methods A decision tree model was used to estimate the cost and quality-adjusted life-years (QALYs) of VDS in a patient aged 2 to 60 months with a clinical diagnosis of community-acquired pneumonia requiring in-hospital management. Multiple sensitivity analyses were conducted to evaluate the robustness of the model. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180. Results The QALYs per person were 0,93 with VDS and 0,92 without VDS. The total costs per person were US$ 1148 for VDS and US$ 1284 without VDS. This position of absolute dominance of VDS makes it unnecessary to estimate the incremental cost-effectiveness ratio. The ICER was sensitive to changes in the relative risk of Vitamin D supplementation. Conclusion In conclusion, our study shows that VDS is a cost-effective to reduce the incidence rate of repeat episodes of pneumonia in children, from a societal perspective. However, the sensitivity of ICER to relative risk makes it necessary to take the results of this economic evaluation with caution.https://doi.org/10.1186/s12962-024-00589-2Health economicsPublic healthHealthcareColombiaCorticosteroids |
| spellingShingle | Jefferson Antonio Buendía Diana Guerrero Patiño Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in children Cost Effectiveness and Resource Allocation Health economics Public health Healthcare Colombia Corticosteroids |
| title | Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in children |
| title_full | Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in children |
| title_fullStr | Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in children |
| title_full_unstemmed | Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in children |
| title_short | Cost-effectiveness of high-dose vitamin D supplementation to reduce the occurrence of repeat episodes of pneumonia in children |
| title_sort | cost effectiveness of high dose vitamin d supplementation to reduce the occurrence of repeat episodes of pneumonia in children |
| topic | Health economics Public health Healthcare Colombia Corticosteroids |
| url | https://doi.org/10.1186/s12962-024-00589-2 |
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