Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity

Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity

Summary: Orexin/hypocretin receptor type 2 (Ox2R), which is widely expressed in the brain, receives orexin signals and modulates sleep and metabolism. Ox2R selective agonists are currently under clinical trials for narcolepsy treatment. Here, we focused on Ox2R expression and function in melanin-con...

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Bibliographic Details
Main Authors: Shuntaro Izawa, Debora Fusca, Hong Jiang, Christian Heilinger, A. Christine Hausen, F. Thomas Wunderlich, Lukas Steuernagel, Peter Kloppenburg, Jens C. Brüning
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725000488
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