6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats
BackgroundCancer remains a predominant cause of death worldwide. The advent of effective chemotherapy has enormously decreased the mortality rate and increased the life expectancy of cancer patients. However, the adverse effects allied with chemotherapy contribute to the development of neurotoxicity...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1486918/full |
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| author | Shehla Akbar Fazal Subhan Rida Qamar Aroosha Akbar Naila Shahbaz Muhammad Aamir Nayyer Siddique Salman Ul Islam |
| author_facet | Shehla Akbar Fazal Subhan Rida Qamar Aroosha Akbar Naila Shahbaz Muhammad Aamir Nayyer Siddique Salman Ul Islam |
| author_sort | Shehla Akbar |
| collection | DOAJ |
| description | BackgroundCancer remains a predominant cause of death worldwide. The advent of effective chemotherapy has enormously decreased the mortality rate and increased the life expectancy of cancer patients. However, the adverse effects allied with chemotherapy contribute to the development of neurotoxicity, anxiety, and depression.ObjectiveThe dual effects of a novel flavanone, 6-hydroxyflavanone (6-HF), were investigated in treating chemotherapy-induced neuropathy along with anxiolytic propensity.MethodsThe anti-neuropathy propensity of 6-HF was evaluated utilizing the cisplatin-induced neuropathy (CIN) model, whereas its anxiolytic activity was evaluated utilizing anxiety models, such as the elevated plus maze test (EPM), the staircase test, and the open-field paradigm.ResultCisplatin administration induced static and dynamic allodynia in the rats. Concomitant administration of 6-HF and cisplatin for four successive weeks remarkably reduced the chemotherapy-induced mechanical allodynia, evident from an elevation in the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL). The anxiolytic-like activity of 6-HF in the EPM apparatus was confirmed by the increased number of entries in the open arm and time spent at the central platform, which was further confirmed by the enhanced head-dipping frequency in the same assay. A decrease in rearing behavior of the mice without suppression of the steps ascended further assured the anxiolytic-like potential of 6-HF. Additionally, the animals under investigation spent more time at the intersection of the open-field apparatus, further confirming the anxiolytic potential of 6-HF.Conclusion6-HF might be considered a potential therapeutic agent for counteracting two common adverse effects of chemotherapy, neurotoxicity and anxiety. |
| format | Article |
| id | doaj-art-5c4ad6bea83f40a48cf7932c7fb3ad12 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-5c4ad6bea83f40a48cf7932c7fb3ad122024-12-18T10:47:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.148691814869186-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley ratsShehla Akbar0Fazal Subhan1Rida Qamar2Aroosha Akbar3Naila Shahbaz4Muhammad Aamir5Nayyer Siddique6Salman Ul Islam7Department of Pharmacy, CECOS University of IT and Emerging Sciences, Peshawar, PakistanDepartment of Pharmacy, CECOS University of IT and Emerging Sciences, Peshawar, PakistanArmed Forces Institute of Dentistry, Army Medical College, Rawalpindi, PakistanDepartment of Physical Therapy, Northwest College of Rehabilitation Sciences, Northwest Institute of Health Sciences, Peshawar, PakistanDepartment of Pharmacy, Sarhad Institute of Science and Information Technology, Peshawar, PakistanDepartment of Pharmacy, The University of Lahore, Lahore, PakistanDepartment of Molecular Biology and Genetics, Khyber Medical University, Peshawar, PakistanDepartment of Pharmacy, International Institute of Science, Arts, and Technology (IISAT), Gujranwala, PakistanBackgroundCancer remains a predominant cause of death worldwide. The advent of effective chemotherapy has enormously decreased the mortality rate and increased the life expectancy of cancer patients. However, the adverse effects allied with chemotherapy contribute to the development of neurotoxicity, anxiety, and depression.ObjectiveThe dual effects of a novel flavanone, 6-hydroxyflavanone (6-HF), were investigated in treating chemotherapy-induced neuropathy along with anxiolytic propensity.MethodsThe anti-neuropathy propensity of 6-HF was evaluated utilizing the cisplatin-induced neuropathy (CIN) model, whereas its anxiolytic activity was evaluated utilizing anxiety models, such as the elevated plus maze test (EPM), the staircase test, and the open-field paradigm.ResultCisplatin administration induced static and dynamic allodynia in the rats. Concomitant administration of 6-HF and cisplatin for four successive weeks remarkably reduced the chemotherapy-induced mechanical allodynia, evident from an elevation in the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL). The anxiolytic-like activity of 6-HF in the EPM apparatus was confirmed by the increased number of entries in the open arm and time spent at the central platform, which was further confirmed by the enhanced head-dipping frequency in the same assay. A decrease in rearing behavior of the mice without suppression of the steps ascended further assured the anxiolytic-like potential of 6-HF. Additionally, the animals under investigation spent more time at the intersection of the open-field apparatus, further confirming the anxiolytic potential of 6-HF.Conclusion6-HF might be considered a potential therapeutic agent for counteracting two common adverse effects of chemotherapy, neurotoxicity and anxiety.https://www.frontiersin.org/articles/10.3389/fphar.2024.1486918/fullchemotherapy6-hydroxyflavanoneneurotoxicityanxietycancer |
| spellingShingle | Shehla Akbar Fazal Subhan Rida Qamar Aroosha Akbar Naila Shahbaz Muhammad Aamir Nayyer Siddique Salman Ul Islam 6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats Frontiers in Pharmacology chemotherapy 6-hydroxyflavanone neurotoxicity anxiety cancer |
| title | 6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats |
| title_full | 6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats |
| title_fullStr | 6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats |
| title_full_unstemmed | 6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats |
| title_short | 6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats |
| title_sort | 6 hydroxyflavanone treats anxiety and chemotherapy induced neuropathy in sprague dawley rats |
| topic | chemotherapy 6-hydroxyflavanone neurotoxicity anxiety cancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1486918/full |
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