Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells

Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells

Abstract Background Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of lipid metabolism in CD4+ tumor-infiltrating lymphocytes (TILs) remains poorly understood. Here, we elucidated that role of stearoyl-CoA...

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Bibliographic Details
Main Authors: Sung-Hyun Hwang, Yeseul Yang, Jae-Ha Jung, Jin Won Kim, Yongbaek Kim
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell & Bioscience
Subjects:
Tumor-infiltrating lymphocyte
CD4+ T cell
SCD
Lipid metabolism
CXCL11
CXCR3
Online Access:https://doi.org/10.1186/s13578-024-01308-3
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