Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study
Abstract. Background:. Huaier granule is an important medicinal fungus extract widely used in cancer treatment. Previous retrospective studies have reported its effectiveness in breast cancer patients, but the imbalanced baseline characteristics of participants could have biased the results. Theref...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-01-01
|
| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002966 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550765903052800 |
|---|---|
| author | Qianqian Guo Yuting Peng Ge Zhang Huan Lin Qianjun Chen Sihan Zhou Xiuyuan Hao |
| author_facet | Qianqian Guo Yuting Peng Ge Zhang Huan Lin Qianjun Chen Sihan Zhou Xiuyuan Hao |
| author_sort | Qianqian Guo |
| collection | DOAJ |
| description | Abstract.
Background:. Huaier granule is an important medicinal fungus extract widely used in cancer treatment. Previous retrospective studies have reported its effectiveness in breast cancer patients, but the imbalanced baseline characteristics of participants could have biased the results. Therefore, this retrospective study aimed to examine the efficacy of Huaier granule on the prognosis of breast cancer patients.
Methods:. In this single-center cohort study, breast cancer patients diagnosed and treated at the Guangdong Provincial Hospital of Chinese Medicine between 2009 and 2017 were selected. The data were retrospectively analyzed and divided into two groups according to whether the patients received Huaier granules. The propensity score matching (PSM) method was used to eliminate selection bias. The disease-free survival (DFS) and overall survival (OS) for these groups were compared using the Kaplan–Meier method and the Cox regression.
Results:. This study included 214 early invasive breast cancer patients, 107 in the Huaier group and 107 in the control group. In the Kaplan–Meier analysis, the 2-year and 5-year DFS rates were significantly different in the Huaier group and control group (hazard ratio [HR], 0.495; 95% confidence interval [CI], 0.257–0.953; P = 0.023). The 2-year and 5-year OS rates were also significantly different (HR, 0.308; 95% CI, 0.148–0.644; P = 0.001). On multivariable Cox regression, Huaier granule was associated with improved DFS (HR, 0.440; 95% CI, 0.223–0.868; P = 0.018) and OS (HR, 0.236; 95% CI, 0.103–0.540; P = 0.001).
Conclusion:. In this retrospective study, Huaier granules improved the DFS and OS of early invasive breast cancer patients, providing real-world evidence for further prospective studies on treating breast cancer with Huaier granules. |
| format | Article |
| id | doaj-art-5c37eba392b94bc0b7a78c3cc10be440 |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-5c37eba392b94bc0b7a78c3cc10be4402025-01-10T01:10:37ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-01-011381939810.1097/CM9.0000000000002966202501050-00011Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective studyQianqian Guo0Yuting Peng1Ge Zhang2Huan Lin3Qianjun Chen4Sihan ZhouXiuyuan Hao1 Breast Department, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong 510006, China2 The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China3 Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China1 Breast Department, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong 510006, China1 Breast Department, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong 510006, ChinaAbstract. Background:. Huaier granule is an important medicinal fungus extract widely used in cancer treatment. Previous retrospective studies have reported its effectiveness in breast cancer patients, but the imbalanced baseline characteristics of participants could have biased the results. Therefore, this retrospective study aimed to examine the efficacy of Huaier granule on the prognosis of breast cancer patients. Methods:. In this single-center cohort study, breast cancer patients diagnosed and treated at the Guangdong Provincial Hospital of Chinese Medicine between 2009 and 2017 were selected. The data were retrospectively analyzed and divided into two groups according to whether the patients received Huaier granules. The propensity score matching (PSM) method was used to eliminate selection bias. The disease-free survival (DFS) and overall survival (OS) for these groups were compared using the Kaplan–Meier method and the Cox regression. Results:. This study included 214 early invasive breast cancer patients, 107 in the Huaier group and 107 in the control group. In the Kaplan–Meier analysis, the 2-year and 5-year DFS rates were significantly different in the Huaier group and control group (hazard ratio [HR], 0.495; 95% confidence interval [CI], 0.257–0.953; P = 0.023). The 2-year and 5-year OS rates were also significantly different (HR, 0.308; 95% CI, 0.148–0.644; P = 0.001). On multivariable Cox regression, Huaier granule was associated with improved DFS (HR, 0.440; 95% CI, 0.223–0.868; P = 0.018) and OS (HR, 0.236; 95% CI, 0.103–0.540; P = 0.001). Conclusion:. In this retrospective study, Huaier granules improved the DFS and OS of early invasive breast cancer patients, providing real-world evidence for further prospective studies on treating breast cancer with Huaier granules.http://journals.lww.com/10.1097/CM9.0000000000002966 |
| spellingShingle | Qianqian Guo Yuting Peng Ge Zhang Huan Lin Qianjun Chen Sihan Zhou Xiuyuan Hao Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study Chinese Medical Journal |
| title | Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study |
| title_full | Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study |
| title_fullStr | Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study |
| title_full_unstemmed | Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study |
| title_short | Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study |
| title_sort | effect of huaier granule on prognosis of breast cancer a single center propensity score matching retrospective study |
| url | http://journals.lww.com/10.1097/CM9.0000000000002966 |
| work_keys_str_mv | AT qianqianguo effectofhuaiergranuleonprognosisofbreastcancerasinglecenterpropensityscorematchingretrospectivestudy AT yutingpeng effectofhuaiergranuleonprognosisofbreastcancerasinglecenterpropensityscorematchingretrospectivestudy AT gezhang effectofhuaiergranuleonprognosisofbreastcancerasinglecenterpropensityscorematchingretrospectivestudy AT huanlin effectofhuaiergranuleonprognosisofbreastcancerasinglecenterpropensityscorematchingretrospectivestudy AT qianjunchen effectofhuaiergranuleonprognosisofbreastcancerasinglecenterpropensityscorematchingretrospectivestudy AT sihanzhou effectofhuaiergranuleonprognosisofbreastcancerasinglecenterpropensityscorematchingretrospectivestudy AT xiuyuanhao effectofhuaiergranuleonprognosisofbreastcancerasinglecenterpropensityscorematchingretrospectivestudy |