The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation

The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation

Abstract Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, the exact mechanisms are not known. A possible pathway could be that Aβ affects the cerebral...

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Main Authors: Mark Bitsch Vestergaard, Aftab Bakhtiari, Merete Osler, Erik Lykke Mortensen, Ulrich Lindberg, Ian Law, Martin Lauritzen, Krisztina Benedek, Henrik Bo Wiberg Larsson
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
β-amyloid
Cerebral blood flow
Cerebrovascular function
Cerebrovascular reactivity
Neurovascular coupling
Aging
Online Access:https://doi.org/10.1186/s13195-024-01652-z
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